Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging
Biological electromagnetic fields arise throughout all tissue depths and types, and correlate with physiological processes and signalling in organs of the body. Most of the methods for monitoring these fields are either highly invasive or spatially coarse. Here, we show that implantable active coil-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2021
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| Online Access: | https://hdl.handle.net/1721.1/130317 |
| _version_ | 1811071235131441152 |
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| author | Hai, Aviad Spanoudaki, Virginia Bartelle, Benjamin B. Jasanoff, Alan Pradip |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Hai, Aviad Spanoudaki, Virginia Bartelle, Benjamin B. Jasanoff, Alan Pradip |
| author_sort | Hai, Aviad |
| collection | MIT |
| description | Biological electromagnetic fields arise throughout all tissue depths and types, and correlate with physiological processes and signalling in organs of the body. Most of the methods for monitoring these fields are either highly invasive or spatially coarse. Here, we show that implantable active coil-based transducers that are detectable via magnetic resonance imaging enable the remote sensing of biological fields. These devices consist of inductively coupled resonant circuits that change their properties in response to electrical or photonic cues, thereby modulating the local magnetic resonance imaging signal without the need for onboard power or wired connectivity. We discuss design parameters relevant to the construction of the transducers on millimetre and submillimetre scales, and demonstrate their in vivo functionality for measuring time-resolved bioluminescence in rodent brains. Biophysical sensing via microcircuits that leverage the capabilities of magnetic resonance imaging may enable a wide range of biological and biomedical applications. |
| first_indexed | 2024-09-23T08:48:03Z |
| format | Article |
| id | mit-1721.1/130317 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:48:03Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1303172022-09-30T11:22:03Z Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging Hai, Aviad Spanoudaki, Virginia Bartelle, Benjamin B. Jasanoff, Alan Pradip Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Koch Institute for Integrative Cancer Research at MIT Biological electromagnetic fields arise throughout all tissue depths and types, and correlate with physiological processes and signalling in organs of the body. Most of the methods for monitoring these fields are either highly invasive or spatially coarse. Here, we show that implantable active coil-based transducers that are detectable via magnetic resonance imaging enable the remote sensing of biological fields. These devices consist of inductively coupled resonant circuits that change their properties in response to electrical or photonic cues, thereby modulating the local magnetic resonance imaging signal without the need for onboard power or wired connectivity. We discuss design parameters relevant to the construction of the transducers on millimetre and submillimetre scales, and demonstrate their in vivo functionality for measuring time-resolved bioluminescence in rodent brains. Biophysical sensing via microcircuits that leverage the capabilities of magnetic resonance imaging may enable a wide range of biological and biomedical applications. NIH grant (R01 NS76462) NIH grant (R01 DA038642) NIH grant (U01 NS904051) 2021-03-31T23:35:59Z 2021-03-31T23:35:59Z 2018-10 2017-12 2019-09-17T13:07:35Z Article http://purl.org/eprint/type/JournalArticle 2157-846X https://hdl.handle.net/1721.1/130317 Hai, Aviad et al., "Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging." Nature Biomedical Engineering 3, 1 (January 2019): 69–78 ©2018 Authors en https://dx.doi.org/10.1038/S41551-018-0309-8 Nature Biomedical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Nature Other repository |
| spellingShingle | Hai, Aviad Spanoudaki, Virginia Bartelle, Benjamin B. Jasanoff, Alan Pradip Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| title | Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| title_full | Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| title_fullStr | Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| title_full_unstemmed | Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| title_short | Wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| title_sort | wireless resonant circuits for minimally invasive sensing of biophysical processes in magnetic resonance imaging |
| url | https://hdl.handle.net/1721.1/130317 |
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