A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2
While facial coverings reduce the spread of SARS-CoV-2 by viral filtration, masks capable of viral inactivation by heating can provide a complementary method to limit transmission. Inspired by reverse-flow chemical reactors, we introduce a new virucidal face mask concept driven by the oscillatory fl...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/130351 |
| _version_ | 1826193528671174656 |
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| author | Faucher, Joseph Lundberg, Daniel James Liang, Xinyao Anna Jin, Xiaojia Cindy Phillips, Rosalie Parviz, Dorsa Buongiorno, Jacopo Strano, Michael S. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Faucher, Joseph Lundberg, Daniel James Liang, Xinyao Anna Jin, Xiaojia Cindy Phillips, Rosalie Parviz, Dorsa Buongiorno, Jacopo Strano, Michael S. |
| author_sort | Faucher, Joseph |
| collection | MIT |
| description | While facial coverings reduce the spread of SARS-CoV-2 by viral filtration, masks capable of viral inactivation by heating can provide a complementary method to limit transmission. Inspired by reverse-flow chemical reactors, we introduce a new virucidal face mask concept driven by the oscillatory flow of human breath. The governing heat and mass transport equations are solved to evaluate virus and CO2 transport. Given limits imposed by the kinetics of SARS-CoV-2 thermal inactivation, human breath, safety, and comfort, heated masks may inactivate SARS-CoV-2 to medical-grade sterility. We detail one design, with a volume of 300 ml at 90°C that achieves a 3-log reduction in viral load with minimal impedance within the mask mesh, with partition coefficient around 2. This is the first quantitative analysis of virucidal thermal inactivation within a protective face mask, and addresses a pressing need for new approaches for personal protective equipment during a global pandemic. |
| first_indexed | 2024-09-23T09:40:33Z |
| format | Article |
| id | mit-1721.1/130351 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:40:33Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1303512022-09-26T13:02:42Z A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 Faucher, Joseph Lundberg, Daniel James Liang, Xinyao Anna Jin, Xiaojia Cindy Phillips, Rosalie Parviz, Dorsa Buongiorno, Jacopo Strano, Michael S. Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Nuclear Science and Engineering While facial coverings reduce the spread of SARS-CoV-2 by viral filtration, masks capable of viral inactivation by heating can provide a complementary method to limit transmission. Inspired by reverse-flow chemical reactors, we introduce a new virucidal face mask concept driven by the oscillatory flow of human breath. The governing heat and mass transport equations are solved to evaluate virus and CO2 transport. Given limits imposed by the kinetics of SARS-CoV-2 thermal inactivation, human breath, safety, and comfort, heated masks may inactivate SARS-CoV-2 to medical-grade sterility. We detail one design, with a volume of 300 ml at 90°C that achieves a 3-log reduction in viral load with minimal impedance within the mask mesh, with partition coefficient around 2. This is the first quantitative analysis of virucidal thermal inactivation within a protective face mask, and addresses a pressing need for new approaches for personal protective equipment during a global pandemic. United States. Office of Naval Research. Division of Graduate Education (Grant/Award 1122374, 1745302) 2021-04-02T14:35:23Z 2021-04-02T14:35:23Z 2021-02 2021-04-01T16:42:31Z Article http://purl.org/eprint/type/JournalArticle 0001-1541 https://hdl.handle.net/1721.1/130351 Faucher, Samuel et al. “A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2.” AIChE Journal (February 2021): e17250 © 2021 The Author(s) en 10.1002/aic.17250 AIChE Journal Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley arXiv |
| spellingShingle | Faucher, Joseph Lundberg, Daniel James Liang, Xinyao Anna Jin, Xiaojia Cindy Phillips, Rosalie Parviz, Dorsa Buongiorno, Jacopo Strano, Michael S. A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 |
| title | A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 |
| title_full | A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 |
| title_fullStr | A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 |
| title_full_unstemmed | A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 |
| title_short | A virucidal face mask based on the reverse-flow reactor concept for thermal inactivation of SARS-CoV-2 |
| title_sort | virucidal face mask based on the reverse flow reactor concept for thermal inactivation of sars cov 2 |
| url | https://hdl.handle.net/1721.1/130351 |
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