Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills
Human Brain Mapping published by Wiley Periodicals, Inc. Developmental dyslexia affects 40–60% of children with a familial risk (FHD+) compared to a general prevalence of 5–10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlyin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/130434 |
| _version_ | 1826198241993031680 |
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| author | Yu, Xi Zuk, Jennifer Perdue, Meaghan V. Ozernov-Palchik, Ola Raney, Talia Beach, Sara Dawley Norton, Elizabeth S. Ou, Yangming Gabrieli, John D. E. Gaab, Nadine |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Yu, Xi Zuk, Jennifer Perdue, Meaghan V. Ozernov-Palchik, Ola Raney, Talia Beach, Sara Dawley Norton, Elizabeth S. Ou, Yangming Gabrieli, John D. E. Gaab, Nadine |
| author_sort | Yu, Xi |
| collection | MIT |
| description | Human Brain Mapping published by Wiley Periodicals, Inc. Developmental dyslexia affects 40–60% of children with a familial risk (FHD+) compared to a general prevalence of 5–10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children remain unknown. Utilizing a retrospective, longitudinal approach, this study examined whether putative protective neural mechanisms can be observed in FHD+Typical at the prereading stage. Functional and structural brain characteristics were examined in 47 FHD+ prereaders who subsequently developed typical (n = 35) or impaired (n = 12) reading abilities and 34 controls (FHD−Typical). Searchlight-based multivariate pattern analyses identified distinct activation patterns during phonological processing between FHD+Typical and FHD−Typical in right inferior frontal gyrus (RIFG) and left temporo-parietal cortex (LTPC) regions. Follow-up analyses on group-specific classification patterns demonstrated LTPC hypoactivation in FHD+Typical compared to FHD−Typical, suggesting this neural characteristic as an FHD+ phenotype. In contrast, RIFG showed hyperactivation in FHD+Typical than FHD−Typical, and its activation pattern was positively correlated with subsequent reading abilities in FHD+ but not controls (FHD−Typical). RIFG hyperactivation in FHD+Typical was further associated with increased interhemispheric functional and structural connectivity. These results suggest that some protective neural mechanisms are already established in FHD+Typical prereaders supporting their typical reading development. |
| first_indexed | 2024-09-23T11:01:38Z |
| format | Article |
| id | mit-1721.1/130434 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:01:38Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1304342021-09-20T18:53:54Z Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills Yu, Xi Zuk, Jennifer Perdue, Meaghan V. Ozernov-Palchik, Ola Raney, Talia Beach, Sara Dawley Norton, Elizabeth S. Ou, Yangming Gabrieli, John D. E. Gaab, Nadine McGovern Institute for Brain Research at MIT Human Brain Mapping published by Wiley Periodicals, Inc. Developmental dyslexia affects 40–60% of children with a familial risk (FHD+) compared to a general prevalence of 5–10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children remain unknown. Utilizing a retrospective, longitudinal approach, this study examined whether putative protective neural mechanisms can be observed in FHD+Typical at the prereading stage. Functional and structural brain characteristics were examined in 47 FHD+ prereaders who subsequently developed typical (n = 35) or impaired (n = 12) reading abilities and 34 controls (FHD−Typical). Searchlight-based multivariate pattern analyses identified distinct activation patterns during phonological processing between FHD+Typical and FHD−Typical in right inferior frontal gyrus (RIFG) and left temporo-parietal cortex (LTPC) regions. Follow-up analyses on group-specific classification patterns demonstrated LTPC hypoactivation in FHD+Typical compared to FHD−Typical, suggesting this neural characteristic as an FHD+ phenotype. In contrast, RIFG showed hyperactivation in FHD+Typical than FHD−Typical, and its activation pattern was positively correlated with subsequent reading abilities in FHD+ but not controls (FHD−Typical). RIFG hyperactivation in FHD+Typical was further associated with increased interhemispheric functional and structural connectivity. These results suggest that some protective neural mechanisms are already established in FHD+Typical prereaders supporting their typical reading development. National Institute of Child Health and Human Development (Awards R01HD067312 and R01HD65762‐01) 2021-04-09T20:17:18Z 2021-04-09T20:17:18Z 2020-03 2020-01 2021-03-19T14:40:40Z Article http://purl.org/eprint/type/JournalArticle 1065-9471 1097-0193 https://hdl.handle.net/1721.1/130434 Yu, Xi et al. "Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills." Human Brain Mapping 41, 10 (March 2020): 2827-2845 © 2020 The Authors en http://dx.doi.org/10.1002/hbm.24980 Human Brain Mapping Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Yu, Xi Zuk, Jennifer Perdue, Meaghan V. Ozernov-Palchik, Ola Raney, Talia Beach, Sara Dawley Norton, Elizabeth S. Ou, Yangming Gabrieli, John D. E. Gaab, Nadine Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| title | Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| title_full | Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| title_fullStr | Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| title_full_unstemmed | Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| title_short | Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| title_sort | putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills |
| url | https://hdl.handle.net/1721.1/130434 |
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