Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2021
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| Online Access: | https://hdl.handle.net/1721.1/130613 |
| _version_ | 1826198089327706112 |
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| author | Arrick, Graham(Graham Philip) |
| author2 | Carlo Giovanni Traverso. |
| author_facet | Carlo Giovanni Traverso. Arrick, Graham(Graham Philip) |
| author_sort | Arrick, Graham(Graham Philip) |
| collection | MIT |
| description | Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020 |
| first_indexed | 2024-09-23T10:58:41Z |
| format | Thesis |
| id | mit-1721.1/130613 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T10:58:41Z |
| publishDate | 2021 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1306132021-05-15T03:24:18Z Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract Arrick, Graham(Graham Philip) Carlo Giovanni Traverso. Massachusetts Institute of Technology. Department of Mechanical Engineering. Massachusetts Institute of Technology. Department of Mechanical Engineering Mechanical Engineering. Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020 Cataloged from the official PDF version of thesis. Includes bibliographical references (pages 59-62). Biologics are a class of therapeutic substances composed of large and complex "macromolecules." Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug's efficacy. Herein lies the goal of this research: to make it possible to successfully deliver a broad set of biologics by mouth. To that end, needleless delivery, or jetting, has been identified as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa. by Graham Arrick. S.M. S.M. Massachusetts Institute of Technology, Department of Mechanical Engineering 2021-05-14T16:29:56Z 2021-05-14T16:29:56Z 2020 2020 Thesis https://hdl.handle.net/1721.1/130613 1249942789 eng MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided. http://dspace.mit.edu/handle/1721.1/7582 69 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Arrick, Graham(Graham Philip) Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| title | Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| title_full | Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| title_fullStr | Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| title_full_unstemmed | Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| title_short | Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| title_sort | delivery of macromolecule therapeutics via jetting in the gastrointestinal tract |
| topic | Mechanical Engineering. |
| url | https://hdl.handle.net/1721.1/130613 |
| work_keys_str_mv | AT arrickgrahamgrahamphilip deliveryofmacromoleculetherapeuticsviajettinginthegastrointestinaltract |