Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface
Thesis: M. Eng. in Advanced Manufacturing and Design, Massachusetts Institute of Technology, Department of Mechanical Engineering, February, 2021
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2021
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| Online Access: | https://hdl.handle.net/1721.1/130722 |
| _version_ | 1826202353177460736 |
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| author | Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology. |
| author2 | David E. Hardt. |
| author_facet | David E. Hardt. Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology. |
| author_sort | Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology. |
| collection | MIT |
| description | Thesis: M. Eng. in Advanced Manufacturing and Design, Massachusetts Institute of Technology, Department of Mechanical Engineering, February, 2021 |
| first_indexed | 2024-09-23T12:06:07Z |
| format | Thesis |
| id | mit-1721.1/130722 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T12:06:07Z |
| publishDate | 2021 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1307222021-05-25T03:25:08Z Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology. David E. Hardt. Massachusetts Institute of Technology. Department of Mechanical Engineering. Massachusetts Institute of Technology. Department of Mechanical Engineering Mechanical Engineering. Thesis: M. Eng. in Advanced Manufacturing and Design, Massachusetts Institute of Technology, Department of Mechanical Engineering, February, 2021 Cataloged from the official PDF of thesis. "February 2021." Includes bibliographical references (page 53). Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte peaks obtained through DESI by improving the temperature uniformity throughout the capillary flow. Multi-channel capillaries were discovered to be more sensitive to temperature and less prone to turbulence under certain conditions when compared to single channel capillaries. A multiple regression analysis reveals the significance of the surface-area-to-volume ratio, inlet-to-outlet area ratio, and the interaction of these main effects with temperature. This study illustrates the complex tradeoff between desolvation and ion loss, thereby providing a general guideline to instrumentation design for the purpose of maximizing signal intensity of the MS. by Chun-Cheng, Hsu. M. Eng. in Advanced Manufacturing and Design M.Eng.inAdvancedManufacturingandDesign Massachusetts Institute of Technology, Department of Mechanical Engineering 2021-05-24T19:53:01Z 2021-05-24T19:53:01Z 2020 2021 Thesis https://hdl.handle.net/1721.1/130722 1251803670 eng MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided. http://dspace.mit.edu/handle/1721.1/7582 53 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology. Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface |
| title | Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface |
| title_full | Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface |
| title_fullStr | Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface |
| title_full_unstemmed | Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface |
| title_short | Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface |
| title_sort | investigation of ion transfer efficiency through multi channel capillaries for a desorption electrospray ionization desi interface |
| topic | Mechanical Engineering. |
| url | https://hdl.handle.net/1721.1/130722 |
| work_keys_str_mv | AT hsuchunchengmengmassachusettsinstituteoftechnology investigationofiontransferefficiencythroughmultichannelcapillariesforadesorptionelectrosprayionizationdesiinterface |