A rapidly deployable individualized system for augmenting ventilator capacity
Strategies to split ventilators to support multiple patients requiring ventilatory support have been proposed and used in emergency cases in which shortages of ventilators cannot otherwise be remedied by production or procurement strategies. However, the current approaches to ventilator sharing lack...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/130989 |
| _version_ | 1826214506558128128 |
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| author | Srinivasan, Shriya Sruthi Ramadi, Khalil Vicario, Francesco Gwynne, Declan A Hayward, Alison M Lagier, David Langer, Robert S Frassica, Joseph J. Baron, Rebecca M. Traverso, Carlo Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Srinivasan, Shriya Sruthi Ramadi, Khalil Vicario, Francesco Gwynne, Declan A Hayward, Alison M Lagier, David Langer, Robert S Frassica, Joseph J. Baron, Rebecca M. Traverso, Carlo Giovanni |
| author_sort | Srinivasan, Shriya Sruthi |
| collection | MIT |
| description | Strategies to split ventilators to support multiple patients requiring ventilatory support have been proposed and used in emergency cases in which shortages of ventilators cannot otherwise be remedied by production or procurement strategies. However, the current approaches to ventilator sharing lack the ability to individualize ventilation to each patient, measure pulmonary mechanics, and accommodate rebalancing of the airflow when one patient improves or deteriorates, posing safety concerns to patients. Potential cross-contamination, lack of alarms, insufficient monitoring, and inability to adapt to sudden changes in patient status have prevented widespread acceptance of ventilator sharing. We have developed an individualized system for augmenting ventilator efficacy (iSAVE) as a rapidly deployable platform that uses a single ventilator to simultaneously and more safely support two individuals. The iSAVE enables individual-specific volume and pressure control and the rebalancing of ventilation in response to improvement or deterioration in an individual's respiratory status. The iSAVE incorporates mechanisms to measure pulmonary mechanics, mitigate cross-contamination and backflow, and accommodate sudden flow changes due to individual interdependencies within the respiratory circuit. We demonstrate these capacities through validation using closed- and open-circuit ventilators on linear test lungs. We show that the iSAVE can temporarily ventilate two pigs on one ventilator as efficaciously as each pig on its own ventilator. By leveraging off-the-shelf medical components, the iSAVE could rapidly expand the ventilation capacity of health care facilities during emergency situations such as pandemics. |
| first_indexed | 2024-09-23T16:06:32Z |
| format | Article |
| id | mit-1721.1/130989 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:06:32Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1309892022-09-29T18:16:39Z A rapidly deployable individualized system for augmenting ventilator capacity Srinivasan, Shriya Sruthi Ramadi, Khalil Vicario, Francesco Gwynne, Declan A Hayward, Alison M Lagier, David Langer, Robert S Frassica, Joseph J. Baron, Rebecca M. Traverso, Carlo Giovanni Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science Koch Institute for Integrative Cancer Research at MIT Strategies to split ventilators to support multiple patients requiring ventilatory support have been proposed and used in emergency cases in which shortages of ventilators cannot otherwise be remedied by production or procurement strategies. However, the current approaches to ventilator sharing lack the ability to individualize ventilation to each patient, measure pulmonary mechanics, and accommodate rebalancing of the airflow when one patient improves or deteriorates, posing safety concerns to patients. Potential cross-contamination, lack of alarms, insufficient monitoring, and inability to adapt to sudden changes in patient status have prevented widespread acceptance of ventilator sharing. We have developed an individualized system for augmenting ventilator efficacy (iSAVE) as a rapidly deployable platform that uses a single ventilator to simultaneously and more safely support two individuals. The iSAVE enables individual-specific volume and pressure control and the rebalancing of ventilation in response to improvement or deterioration in an individual's respiratory status. The iSAVE incorporates mechanisms to measure pulmonary mechanics, mitigate cross-contamination and backflow, and accommodate sudden flow changes due to individual interdependencies within the respiratory circuit. We demonstrate these capacities through validation using closed- and open-circuit ventilators on linear test lungs. We show that the iSAVE can temporarily ventilate two pigs on one ventilator as efficaciously as each pig on its own ventilator. By leveraging off-the-shelf medical components, the iSAVE could rapidly expand the ventilation capacity of health care facilities during emergency situations such as pandemics. 2021-06-16T20:38:30Z 2021-06-16T20:38:30Z 2020-05 2020-04 2021-06-15T18:16:50Z Article http://purl.org/eprint/type/JournalArticle 1946-6234 1946-6242 https://hdl.handle.net/1721.1/130989 Srinivasan, Shriya S. et al. "A rapidly deployable individualized system for augmenting ventilator capacity." Science Translational Medicine 12, 549 (May 2020): eabb9401. © 2020 The Authors en http://dx.doi.org/10.1126/scitranslmed.abb9401 Science Translational Medicine Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Other repository |
| spellingShingle | Srinivasan, Shriya Sruthi Ramadi, Khalil Vicario, Francesco Gwynne, Declan A Hayward, Alison M Lagier, David Langer, Robert S Frassica, Joseph J. Baron, Rebecca M. Traverso, Carlo Giovanni A rapidly deployable individualized system for augmenting ventilator capacity |
| title | A rapidly deployable individualized system for augmenting ventilator capacity |
| title_full | A rapidly deployable individualized system for augmenting ventilator capacity |
| title_fullStr | A rapidly deployable individualized system for augmenting ventilator capacity |
| title_full_unstemmed | A rapidly deployable individualized system for augmenting ventilator capacity |
| title_short | A rapidly deployable individualized system for augmenting ventilator capacity |
| title_sort | rapidly deployable individualized system for augmenting ventilator capacity |
| url | https://hdl.handle.net/1721.1/130989 |
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