Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Effective treatment of pediatric solid tumors has been hampered by the predominance of currently "undruggable" driver transcription factors. Improving outcomes while decreasing the toxicity of treatment necessitates the development of novel agents that can directly inhibit or degrade these...

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Bibliographic Details
Main Authors: Wolpaw, Adam J., Bayliss, Richard, Büchel, Gabriele, Dang, Chi V., Eilers, Martin, Gustafson, W. Clay, Hansen, Gwenn H., Jura, Natalia, Knapp, Stefan, Lemmon, Mark A., Levens, David, Maris, John M., Marmorstein, Ronen, Metallo, Steven J., Park, Julie R., Penn, Linda Z., Rape, Michael, Roussel, Martine F., Shokat, Kevan M., Tansey, William P., Verba, Kliment A., Vos, Seychelle M., Weiss, William A., Wolf, Elmar, Mossé, Yaël P.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Association for Cancer Research (AACR) 2021
Online Access:https://hdl.handle.net/1721.1/131155

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