UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic
Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in the United States and many parts of the world, heal...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021
|
| Online Access: | https://hdl.handle.net/1721.1/131160 |
| _version_ | 1811076870690570240 |
|---|---|
| author | Weaver, Davis T. McElvany, Benjamin D. Gopalakrishnan, Vishhvaan Card, Kyle J. Crozier, Dena Dhawan, Andrew Dinh, Mina N. Dolson, Emily Farrokhian, Nathan Hitomi, Masahiro Ho, Emily Jagdish, Tanush King, Eshan S. Cadnum, Jennifer L. Donskey, Curtis J. Krishnan, Nikhil Kuzmin, Gleb Li, Ju Maltas, Jeff Mo, Jinhan Pelesko, Julia Scarborough, Jessica A. Sedor, Geoff Tian, Enze An, Gary C. Diehl, Sean A. Scott, Jacob G. |
| author2 | Massachusetts Institute of Technology. Department of Nuclear Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Weaver, Davis T. McElvany, Benjamin D. Gopalakrishnan, Vishhvaan Card, Kyle J. Crozier, Dena Dhawan, Andrew Dinh, Mina N. Dolson, Emily Farrokhian, Nathan Hitomi, Masahiro Ho, Emily Jagdish, Tanush King, Eshan S. Cadnum, Jennifer L. Donskey, Curtis J. Krishnan, Nikhil Kuzmin, Gleb Li, Ju Maltas, Jeff Mo, Jinhan Pelesko, Julia Scarborough, Jessica A. Sedor, Geoff Tian, Enze An, Gary C. Diehl, Sean A. Scott, Jacob G. |
| author_sort | Weaver, Davis T. |
| collection | MIT |
| description | Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in the United States and many parts of the world, healthcare provider demand for these necessities is currently outpacing supply. In the midst of the current pandemic, there has been a concerted effort to identify viable ways to conserve PPE, including decontamination after use. In this study, we outline a procedure by which PPE may be decontaminated using ultraviolet (UV) radiation in biosafety cabinets (BSCs), a common element of many academic, public health, and hospital laboratories. According to the literature, effective decontamination of N95 respirator masks or surgical masks requires UV-C doses of greater than 1 Jcm⁻², which was achieved after 4.3 hours per side when placing the N95 at the bottom of the BSCs tested in this study. We then demonstrated complete inactivation of the human coronavirus NL63 on N95 mask material after 15 minutes of UV-C exposure at 61 cm (232 μWcm⁻²). Our results provide support to healthcare organizations looking for methods to extend their reserves of PPE. |
| first_indexed | 2024-09-23T10:29:17Z |
| format | Article |
| id | mit-1721.1/131160 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:29:17Z |
| publishDate | 2021 |
| publisher | Public Library of Science (PLoS) |
| record_format | dspace |
| spelling | mit-1721.1/1311602022-09-27T09:46:18Z UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic Weaver, Davis T. McElvany, Benjamin D. Gopalakrishnan, Vishhvaan Card, Kyle J. Crozier, Dena Dhawan, Andrew Dinh, Mina N. Dolson, Emily Farrokhian, Nathan Hitomi, Masahiro Ho, Emily Jagdish, Tanush King, Eshan S. Cadnum, Jennifer L. Donskey, Curtis J. Krishnan, Nikhil Kuzmin, Gleb Li, Ju Maltas, Jeff Mo, Jinhan Pelesko, Julia Scarborough, Jessica A. Sedor, Geoff Tian, Enze An, Gary C. Diehl, Sean A. Scott, Jacob G. Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in the United States and many parts of the world, healthcare provider demand for these necessities is currently outpacing supply. In the midst of the current pandemic, there has been a concerted effort to identify viable ways to conserve PPE, including decontamination after use. In this study, we outline a procedure by which PPE may be decontaminated using ultraviolet (UV) radiation in biosafety cabinets (BSCs), a common element of many academic, public health, and hospital laboratories. According to the literature, effective decontamination of N95 respirator masks or surgical masks requires UV-C doses of greater than 1 Jcm⁻², which was achieved after 4.3 hours per side when placing the N95 at the bottom of the BSCs tested in this study. We then demonstrated complete inactivation of the human coronavirus NL63 on N95 mask material after 15 minutes of UV-C exposure at 61 cm (232 μWcm⁻²). Our results provide support to healthcare organizations looking for methods to extend their reserves of PPE. 2021-08-10T17:37:22Z 2021-08-10T17:37:22Z 2021-07 2020-10 2021-08-05T18:36:17Z Article http://purl.org/eprint/type/JournalArticle 1932-6203 https://hdl.handle.net/1721.1/131160 Weaver Davis T. et al. "UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic." PLoS ONE 16, 7 (July 2021): e0241734. © 2021 Weaver et al. en http://dx.doi.org/10.1371/journal.pone.0241734 PLOS ONE Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science (PLoS) PLoS |
| spellingShingle | Weaver, Davis T. McElvany, Benjamin D. Gopalakrishnan, Vishhvaan Card, Kyle J. Crozier, Dena Dhawan, Andrew Dinh, Mina N. Dolson, Emily Farrokhian, Nathan Hitomi, Masahiro Ho, Emily Jagdish, Tanush King, Eshan S. Cadnum, Jennifer L. Donskey, Curtis J. Krishnan, Nikhil Kuzmin, Gleb Li, Ju Maltas, Jeff Mo, Jinhan Pelesko, Julia Scarborough, Jessica A. Sedor, Geoff Tian, Enze An, Gary C. Diehl, Sean A. Scott, Jacob G. UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic |
| title | UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic |
| title_full | UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic |
| title_fullStr | UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic |
| title_full_unstemmed | UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic |
| title_short | UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic |
| title_sort | uv decontamination of personal protective equipment with idle laboratory biosafety cabinets during the covid 19 pandemic |
| url | https://hdl.handle.net/1721.1/131160 |
| work_keys_str_mv | AT weaverdavist uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT mcelvanybenjamind uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT gopalakrishnanvishhvaan uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT cardkylej uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT crozierdena uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT dhawanandrew uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT dinhminan uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT dolsonemily uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT farrokhiannathan uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT hitomimasahiro uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT hoemily uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT jagdishtanush uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT kingeshans uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT cadnumjenniferl uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT donskeycurtisj uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT krishnannikhil uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT kuzmingleb uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT liju uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT maltasjeff uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT mojinhan uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT peleskojulia uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT scarboroughjessicaa uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT sedorgeoff uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT tianenze uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT angaryc uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT diehlseana uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic AT scottjacobg uvdecontaminationofpersonalprotectiveequipmentwithidlelaboratorybiosafetycabinetsduringthecovid19pandemic |