Core commitments for field trials of gene drive organisms
Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread a desired allele through a population, have the potential to transform the way societies address a wide range of daunting public health and environmental challenges. The development, testing, and release of GDOs, h...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/131220 |
| _version_ | 1811069656336695296 |
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| author | Long, Kanya C. Alphey, Luke Annas, George J. Bloss, Cinnamon S. Campbell, Karl J. Champer, Jackson Chen, Chun-Hong Choudhary, Amit Church, George M. Collins, James P. Cooper, Kimberly L. Delborne, Jason A. Edwards, Owain R. Emerson, Claudia I. Esvelt, Kevin Michael Evans, Sam Weiss Friedman, Robert M. Gantz, Valentino M. Gould, Fred Hartley, Sarah Heitman, Elizabeth Hemingway, Janet Kanuka, Hirotaka Kuzma, Jennifer Lavery, James V. Lee, Yoosook Lorenzen, Marce Lunshof, Jeantine E. Marshall, John M. Messer, Philipp W. Montell, Craig Oye, Kenneth A. Palmer, Megan J. Papathanos, Philippos Aris Paradkar, Prasad N. Piaggio, Antoinette J. Rasgon, Jason L. Rašić, Gordana Rudenko, Larisa Saah, J. Royden Scott, Maxwell J. Sutton, Jolene T. Vorsino, Adam E. Akbari, Omar S. |
| author2 | Massachusetts Institute of Technology. Media Laboratory |
| author_facet | Massachusetts Institute of Technology. Media Laboratory Long, Kanya C. Alphey, Luke Annas, George J. Bloss, Cinnamon S. Campbell, Karl J. Champer, Jackson Chen, Chun-Hong Choudhary, Amit Church, George M. Collins, James P. Cooper, Kimberly L. Delborne, Jason A. Edwards, Owain R. Emerson, Claudia I. Esvelt, Kevin Michael Evans, Sam Weiss Friedman, Robert M. Gantz, Valentino M. Gould, Fred Hartley, Sarah Heitman, Elizabeth Hemingway, Janet Kanuka, Hirotaka Kuzma, Jennifer Lavery, James V. Lee, Yoosook Lorenzen, Marce Lunshof, Jeantine E. Marshall, John M. Messer, Philipp W. Montell, Craig Oye, Kenneth A. Palmer, Megan J. Papathanos, Philippos Aris Paradkar, Prasad N. Piaggio, Antoinette J. Rasgon, Jason L. Rašić, Gordana Rudenko, Larisa Saah, J. Royden Scott, Maxwell J. Sutton, Jolene T. Vorsino, Adam E. Akbari, Omar S. |
| author_sort | Long, Kanya C. |
| collection | MIT |
| description | Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread a desired allele through a population, have the potential to transform the way societies address a wide range of daunting public health and environmental challenges. The development, testing, and release of GDOs, however, are complex and often controversial. A key challenge is to clarify the appropriate roles of developers and others actively engaged in work with GDOs in decision-making processes, and, in particular, how to establish partnerships with relevant authorities and other stakeholders. Several members of the gene drive community previously proposed safeguards for laboratory experiments with GDOs (1) that, in the absence of national or international guidelines, were considered essential for responsible laboratory work to proceed. Now, with GDO development advancing in laboratories (2–5), we envision similar safeguards for the potential next step: ecologically and/or genetically confined field trials to further assess the performance of GDOs. A GDO's propensity to spread necessitates well-developed criteria for field trials to assess its potential impacts (6). We, as a multidisciplinary group of GDO developers, ecologists, conservation biologists, and experts in social science, ethics, and policy, outline commitments below that we deem critical for responsible conduct of a field trial and to ensure that these technologies, if they are introduced, serve the public interest. |
| first_indexed | 2024-09-23T08:13:50Z |
| format | Article |
| id | mit-1721.1/131220 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:13:50Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1312202022-09-23T11:47:31Z Core commitments for field trials of gene drive organisms Long, Kanya C. Alphey, Luke Annas, George J. Bloss, Cinnamon S. Campbell, Karl J. Champer, Jackson Chen, Chun-Hong Choudhary, Amit Church, George M. Collins, James P. Cooper, Kimberly L. Delborne, Jason A. Edwards, Owain R. Emerson, Claudia I. Esvelt, Kevin Michael Evans, Sam Weiss Friedman, Robert M. Gantz, Valentino M. Gould, Fred Hartley, Sarah Heitman, Elizabeth Hemingway, Janet Kanuka, Hirotaka Kuzma, Jennifer Lavery, James V. Lee, Yoosook Lorenzen, Marce Lunshof, Jeantine E. Marshall, John M. Messer, Philipp W. Montell, Craig Oye, Kenneth A. Palmer, Megan J. Papathanos, Philippos Aris Paradkar, Prasad N. Piaggio, Antoinette J. Rasgon, Jason L. Rašić, Gordana Rudenko, Larisa Saah, J. Royden Scott, Maxwell J. Sutton, Jolene T. Vorsino, Adam E. Akbari, Omar S. Massachusetts Institute of Technology. Media Laboratory Gene drive organisms (GDOs), whose genomes have been genetically engineered to spread a desired allele through a population, have the potential to transform the way societies address a wide range of daunting public health and environmental challenges. The development, testing, and release of GDOs, however, are complex and often controversial. A key challenge is to clarify the appropriate roles of developers and others actively engaged in work with GDOs in decision-making processes, and, in particular, how to establish partnerships with relevant authorities and other stakeholders. Several members of the gene drive community previously proposed safeguards for laboratory experiments with GDOs (1) that, in the absence of national or international guidelines, were considered essential for responsible laboratory work to proceed. Now, with GDO development advancing in laboratories (2–5), we envision similar safeguards for the potential next step: ecologically and/or genetically confined field trials to further assess the performance of GDOs. A GDO's propensity to spread necessitates well-developed criteria for field trials to assess its potential impacts (6). We, as a multidisciplinary group of GDO developers, ecologists, conservation biologists, and experts in social science, ethics, and policy, outline commitments below that we deem critical for responsible conduct of a field trial and to ensure that these technologies, if they are introduced, serve the public interest. 2021-08-31T14:11:00Z 2021-08-31T14:11:00Z 2020-12 2021-08-24T13:41:21Z Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 https://hdl.handle.net/1721.1/131220 Long, Kanya C. et al. "Core commitments for field trials of gene drive organisms." Science 370, 6523 (December 2020): 1417-1419. © 2020 American Association for the Advancement of Science en http://dx.doi.org/10.1126/science.abd1908 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Prof. Esvelt via Elizabeth Soergel |
| spellingShingle | Long, Kanya C. Alphey, Luke Annas, George J. Bloss, Cinnamon S. Campbell, Karl J. Champer, Jackson Chen, Chun-Hong Choudhary, Amit Church, George M. Collins, James P. Cooper, Kimberly L. Delborne, Jason A. Edwards, Owain R. Emerson, Claudia I. Esvelt, Kevin Michael Evans, Sam Weiss Friedman, Robert M. Gantz, Valentino M. Gould, Fred Hartley, Sarah Heitman, Elizabeth Hemingway, Janet Kanuka, Hirotaka Kuzma, Jennifer Lavery, James V. Lee, Yoosook Lorenzen, Marce Lunshof, Jeantine E. Marshall, John M. Messer, Philipp W. Montell, Craig Oye, Kenneth A. Palmer, Megan J. Papathanos, Philippos Aris Paradkar, Prasad N. Piaggio, Antoinette J. Rasgon, Jason L. Rašić, Gordana Rudenko, Larisa Saah, J. Royden Scott, Maxwell J. Sutton, Jolene T. Vorsino, Adam E. Akbari, Omar S. Core commitments for field trials of gene drive organisms |
| title | Core commitments for field trials of gene drive organisms |
| title_full | Core commitments for field trials of gene drive organisms |
| title_fullStr | Core commitments for field trials of gene drive organisms |
| title_full_unstemmed | Core commitments for field trials of gene drive organisms |
| title_short | Core commitments for field trials of gene drive organisms |
| title_sort | core commitments for field trials of gene drive organisms |
| url | https://hdl.handle.net/1721.1/131220 |
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