Biomolecular Condensates and Cancer
Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensa...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
|
| Online Access: | https://hdl.handle.net/1721.1/131226 |
| _version_ | 1826190524334211072 |
|---|---|
| author | Boija, Ann Klein, Isaac A. Young, Richard A. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Boija, Ann Klein, Isaac A. Young, Richard A. |
| author_sort | Boija, Ann |
| collection | MIT |
| description | Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensates are membrane-less bodies, often formed by liquid-liquid phase separation, that compartmentalize protein and RNA molecules with related functions. New insights from condensate studies portend a profound transformation in our understanding of cellular dysregulation in cancer. Here we summarize key features of biomolecular condensates, note where they have been implicated—or will likely be implicated—in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensates, and discuss some of the questions that must be addressed to further advance our understanding and treatment of cancer. |
| first_indexed | 2024-09-23T08:41:16Z |
| format | Article |
| id | mit-1721.1/131226 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:41:16Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1312262022-09-23T13:53:12Z Biomolecular Condensates and Cancer Boija, Ann Klein, Isaac A. Young, Richard A. Massachusetts Institute of Technology. Department of Biology Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensates are membrane-less bodies, often formed by liquid-liquid phase separation, that compartmentalize protein and RNA molecules with related functions. New insights from condensate studies portend a profound transformation in our understanding of cellular dysregulation in cancer. Here we summarize key features of biomolecular condensates, note where they have been implicated—or will likely be implicated—in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensates, and discuss some of the questions that must be addressed to further advance our understanding and treatment of cancer. NIH (Grants GM123511, CA213333 and CA155258) 2021-09-01T14:21:50Z 2021-09-01T14:21:50Z 2021-02 2021-01 2021-08-06T16:57:42Z Article http://purl.org/eprint/type/JournalArticle 1535-6108 https://hdl.handle.net/1721.1/131226 Boija, Ann et al. "Biomolecular Condensates and Cancer." Cancer Cell 39, 2 (February 2021): 174-192. © 2020 Elsevier Inc en http://dx.doi.org/10.1016/j.ccell.2020.12.003 Cancer Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Prof. Richard Young |
| spellingShingle | Boija, Ann Klein, Isaac A. Young, Richard A. Biomolecular Condensates and Cancer |
| title | Biomolecular Condensates and Cancer |
| title_full | Biomolecular Condensates and Cancer |
| title_fullStr | Biomolecular Condensates and Cancer |
| title_full_unstemmed | Biomolecular Condensates and Cancer |
| title_short | Biomolecular Condensates and Cancer |
| title_sort | biomolecular condensates and cancer |
| url | https://hdl.handle.net/1721.1/131226 |
| work_keys_str_mv | AT boijaann biomolecularcondensatesandcancer AT kleinisaaca biomolecularcondensatesandcancer AT youngricharda biomolecularcondensatesandcancer |