Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis
Folding is an important way by which epithelia are sculpted into three-dimensional shapes during development. Recent studies have integrated quantitative image analysis and physical modeling to uncover contributing mechanisms. It is becoming clear that folding processes often employ multiple mechani...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/131254 |
| _version_ | 1826200684319473664 |
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| author | Denk-Lobnig, Marlis Martin, Adam C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Denk-Lobnig, Marlis Martin, Adam C |
| author_sort | Denk-Lobnig, Marlis |
| collection | MIT |
| description | Folding is an important way by which epithelia are sculpted into three-dimensional shapes during development. Recent studies have integrated quantitative image analysis and physical modeling to uncover contributing mechanisms. It is becoming clear that folding processes often employ multiple mechanisms of force generation. Here, we review divergent modes of epithelial folding. We argue that, in many cases, several mechanisms interact at different time-scales and length-scales to generate a fold. In other cases, very similar folds are generated by different folding mechanisms. How one (or a specific combination of) mechanism(s) might be advantageous in one case versus another is not understood, and future work using quantitative analyses and modeling will be required to determine reasons for distinct modes of folding. |
| first_indexed | 2024-09-23T11:40:15Z |
| format | Article |
| id | mit-1721.1/131254 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:40:15Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1312542022-10-01T05:10:39Z Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis Denk-Lobnig, Marlis Martin, Adam C Massachusetts Institute of Technology. Department of Biology Folding is an important way by which epithelia are sculpted into three-dimensional shapes during development. Recent studies have integrated quantitative image analysis and physical modeling to uncover contributing mechanisms. It is becoming clear that folding processes often employ multiple mechanisms of force generation. Here, we review divergent modes of epithelial folding. We argue that, in many cases, several mechanisms interact at different time-scales and length-scales to generate a fold. In other cases, very similar folds are generated by different folding mechanisms. How one (or a specific combination of) mechanism(s) might be advantageous in one case versus another is not understood, and future work using quantitative analyses and modeling will be required to determine reasons for distinct modes of folding. 2021-09-15T19:09:25Z 2021-09-15T19:09:25Z 2020-03 2021-09-13T16:52:53Z Article http://purl.org/eprint/type/JournalArticle 0959-437X https://hdl.handle.net/1721.1/131254 Denk-Lobnig, Marlis and Adam C. Martin. "Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis." Current Opinion in Genetics & Development 63 (August 2020): 24-29. © 2020 Elsevier Ltd en http://dx.doi.org/10.1016/j.gde.2020.02.014 Current Opinion in Genetics & Development Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf application/pdf Elsevier BV Prof. Adam Martin |
| spellingShingle | Denk-Lobnig, Marlis Martin, Adam C Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| title | Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| title_full | Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| title_fullStr | Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| title_full_unstemmed | Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| title_short | Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| title_sort | divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis |
| url | https://hdl.handle.net/1721.1/131254 |
| work_keys_str_mv | AT denklobnigmarlis divergentandcombinatorialmechanicalstrategiesthatpromoteepithelialfoldingduringmorphogenesis AT martinadamc divergentandcombinatorialmechanicalstrategiesthatpromoteepithelialfoldingduringmorphogenesis |