Rapid assessment of T-cell receptor specificity of the immune repertoire
Accurate assessment of T-cell-receptor (TCR)–antigen specificity across the whole immune repertoire lies at the heart of improved cancer immunotherapy, but predictive models capable of high-throughput assessment of TCR–peptide pairs are lacking. Recent advances in deep sequencing and crystallography...
Main Authors: | Lin, Xingcheng, George, Jason T., Schafer, Nicholas P., Ng Chau, Kevin, Birnbaum, Michael E, Clementi, Cecilia, Onuchic, José N., Levine, Herbert |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2021
|
Online Access: | https://hdl.handle.net/1721.1/131255 |
Similar Items
-
Analysis of the B cell receptor repertoire in six immune-mediated diseases
by: Bashford-Rogers, R, et al.
Published: (2019) -
Structural and dynamical order of a disordered protein: molecular insights into conformational switching of PAGE4 at the systems level
by: Lin, Xingcheng, et al.
Published: (2020) -
Scalable methods for immune repertoire sequencing
by: Holec, Patrick
Published: (2023) -
High-throughput methods for characterizing the immune repertoire
by: Laserson, Uri
Published: (2013) -
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults
by: Pan, Yi-Gen, et al.
Published: (2022)