High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain
Abstract Axon diameter and density are important microstructural metrics that offer valuable insight into the structural organization of white matter throughout the human brain. We report the systematic acquisition and analysis of a comprehensive diffusion MRI data set acquired with 300 mT/m maximu...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Berlin Heidelberg
2021
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| Online Access: | https://hdl.handle.net/1721.1/131443 |
| _version_ | 1811081996228624384 |
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| author | Huang, Susie Y Tian, Qiyuan Fan, Qiuyun Witzel, Thomas Wichtmann, Barbara McNab, Jennifer A Daniel Bireley, J. Machado, Natalya Klawiter, Eric C Mekkaoui, Choukri Wald, Lawrence L Nummenmaa, Aapo |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Huang, Susie Y Tian, Qiyuan Fan, Qiuyun Witzel, Thomas Wichtmann, Barbara McNab, Jennifer A Daniel Bireley, J. Machado, Natalya Klawiter, Eric C Mekkaoui, Choukri Wald, Lawrence L Nummenmaa, Aapo |
| author_sort | Huang, Susie Y |
| collection | MIT |
| description | Abstract
Axon diameter and density are important microstructural metrics that offer valuable insight into the structural organization of white matter throughout the human brain. We report the systematic acquisition and analysis of a comprehensive diffusion MRI data set acquired with 300 mT/m maximum gradient strength in a cohort of 20 healthy human subjects that yields distinct and consistent patterns of axon diameter index in white matter tracts of arbitrary orientation. We use a straightforward, previously validated approach to estimating indices of axon diameter and volume fraction that involves interpolating the diffusion signal perpendicular to the principal fiber orientation and fitting a three-compartment model of intra-axonal, extra-axonal and free water diffusion. The resultant maps confirm the presence of larger diameter indices in the body of corpus callosum compared to the genu and splenium, as previously reported, and show larger axon diameter index in the corticospinal tracts compared to adjacent white matter tracts such as the cingulum. An anterior-to-posterior gradient in axon diameter index is also observed, with smaller diameter indices in the frontal lobes and larger diameter indices in the parieto-occipital white matter. These observations are consistent with known trends from prior histologic studies in humans and non-human primates. Rather than serving as fully quantitative measures of axon diameter and density, our results may be considered as axon diameter- and volume fraction-weighted images that appear to be modulated by the underlying microstructure and may capture broad trends in axonal size and packing density, acknowledging that the precise origin of such modulation requires further investigation that will be facilitated by the availability of high gradient strengths for in vivo human imaging. |
| first_indexed | 2024-09-23T11:55:43Z |
| format | Article |
| id | mit-1721.1/131443 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:55:43Z |
| publishDate | 2021 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1314432023-11-08T21:44:59Z High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain Huang, Susie Y Tian, Qiyuan Fan, Qiuyun Witzel, Thomas Wichtmann, Barbara McNab, Jennifer A Daniel Bireley, J. Machado, Natalya Klawiter, Eric C Mekkaoui, Choukri Wald, Lawrence L Nummenmaa, Aapo Harvard University--MIT Division of Health Sciences and Technology Abstract Axon diameter and density are important microstructural metrics that offer valuable insight into the structural organization of white matter throughout the human brain. We report the systematic acquisition and analysis of a comprehensive diffusion MRI data set acquired with 300 mT/m maximum gradient strength in a cohort of 20 healthy human subjects that yields distinct and consistent patterns of axon diameter index in white matter tracts of arbitrary orientation. We use a straightforward, previously validated approach to estimating indices of axon diameter and volume fraction that involves interpolating the diffusion signal perpendicular to the principal fiber orientation and fitting a three-compartment model of intra-axonal, extra-axonal and free water diffusion. The resultant maps confirm the presence of larger diameter indices in the body of corpus callosum compared to the genu and splenium, as previously reported, and show larger axon diameter index in the corticospinal tracts compared to adjacent white matter tracts such as the cingulum. An anterior-to-posterior gradient in axon diameter index is also observed, with smaller diameter indices in the frontal lobes and larger diameter indices in the parieto-occipital white matter. These observations are consistent with known trends from prior histologic studies in humans and non-human primates. Rather than serving as fully quantitative measures of axon diameter and density, our results may be considered as axon diameter- and volume fraction-weighted images that appear to be modulated by the underlying microstructure and may capture broad trends in axonal size and packing density, acknowledging that the precise origin of such modulation requires further investigation that will be facilitated by the availability of high gradient strengths for in vivo human imaging. 2021-09-20T17:17:06Z 2021-09-20T17:17:06Z 2019-09-28 2020-09-24T20:57:45Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/131443 en https://doi.org/10.1007/s00429-019-01961-2 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer-Verlag GmbH Germany, part of Springer Nature application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Huang, Susie Y Tian, Qiyuan Fan, Qiuyun Witzel, Thomas Wichtmann, Barbara McNab, Jennifer A Daniel Bireley, J. Machado, Natalya Klawiter, Eric C Mekkaoui, Choukri Wald, Lawrence L Nummenmaa, Aapo High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| title | High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| title_full | High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| title_fullStr | High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| title_full_unstemmed | High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| title_short | High-gradient diffusion MRI reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| title_sort | high gradient diffusion mri reveals distinct estimates of axon diameter index within different white matter tracts in the in vivo human brain |
| url | https://hdl.handle.net/1721.1/131443 |
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