The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species
Abstract An innovative strategy for sustainably active oxygen capture using nitrogen (N2) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticid...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer US
2021
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| Online Access: | https://hdl.handle.net/1721.1/131896 |
| _version_ | 1811087542380920832 |
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| author | Su, Rui Yu, Wenjing Sun, Kaiju Yang, Jie Chen, Changbao Lian, Wenhui Liu, Shuying Yang, Hongmei |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Su, Rui Yu, Wenjing Sun, Kaiju Yang, Jie Chen, Changbao Lian, Wenhui Liu, Shuying Yang, Hongmei |
| author_sort | Su, Rui |
| collection | MIT |
| description | Abstract
An innovative strategy for sustainably active oxygen capture using nitrogen (N2) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormones, and poly brominated diphenyl ethers by using He and N2 as DART gas, respectively. The unexpectedly characteristic ionization reactions, including replacement reaction where the sulfur atom of P=S group, were replaced by oxygen atom, oxidation ([M + nO + H]+ or [M + nO-H]− (n = 1, 2, 3, 4, 5)), and hydrogen loss (loss of two hydrogens) rapidly occurred in situ in the presence of N2 under ambient conditions without any additives. The reaction mechanisms were proposed and further confirmed by high-resolution tandem mass spectrometry. Our study under high temperature and high voltage provides a powerful tool for generating unique ionic species that may be difficult to form by other means, which also creates favorable conditions for the future study of the mechanism of DART MS.
Graphical Abstract |
| first_indexed | 2024-09-23T13:47:45Z |
| format | Article |
| id | mit-1721.1/131896 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:47:45Z |
| publishDate | 2021 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1318962023-03-15T19:31:39Z The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species Su, Rui Yu, Wenjing Sun, Kaiju Yang, Jie Chen, Changbao Lian, Wenhui Liu, Shuying Yang, Hongmei Massachusetts Institute of Technology. Department of Biological Engineering Abstract An innovative strategy for sustainably active oxygen capture using nitrogen (N2) instead of helium (He) as direct analysis in real-time (DART) gas is demonstrated in this work. DART MS was carried out to analyze different polarity compounds including organophosphorus pesticides, amino acids, hormones, and poly brominated diphenyl ethers by using He and N2 as DART gas, respectively. The unexpectedly characteristic ionization reactions, including replacement reaction where the sulfur atom of P=S group, were replaced by oxygen atom, oxidation ([M + nO + H]+ or [M + nO-H]− (n = 1, 2, 3, 4, 5)), and hydrogen loss (loss of two hydrogens) rapidly occurred in situ in the presence of N2 under ambient conditions without any additives. The reaction mechanisms were proposed and further confirmed by high-resolution tandem mass spectrometry. Our study under high temperature and high voltage provides a powerful tool for generating unique ionic species that may be difficult to form by other means, which also creates favorable conditions for the future study of the mechanism of DART MS. Graphical Abstract 2021-09-20T17:30:50Z 2021-09-20T17:30:50Z 2019-02-19 2020-09-24T21:48:11Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/131896 en https://doi.org/10.1007/s13361-019-02132-7 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. American Society for Mass Spectrometry application/pdf Springer US Springer US |
| spellingShingle | Su, Rui Yu, Wenjing Sun, Kaiju Yang, Jie Chen, Changbao Lian, Wenhui Liu, Shuying Yang, Hongmei The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
| title | The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
| title_full | The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
| title_fullStr | The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
| title_full_unstemmed | The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
| title_short | The Ion Source of Nitrogen Direct Analysis in Real-Time Mass Spectrometry as a Highly Efficient Reactor: Generation of Reactive Oxygen Species |
| title_sort | ion source of nitrogen direct analysis in real time mass spectrometry as a highly efficient reactor generation of reactive oxygen species |
| url | https://hdl.handle.net/1721.1/131896 |
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