Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk?
Abstract Purpose Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men. Methods Re...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer US
2021
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| Online Access: | https://hdl.handle.net/1721.1/131908 |
| _version_ | 1826202927808643072 |
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| author | Coopey, Suzanne B Kartal, Kinyas Li, Clara Yala, Adam Barzilay, Regina Faulkner, Heather R King, Tari A Acevedo, Francisco Garber, Judy E Guidi, Anthony J Hughes, Kevin S |
| author_facet | Coopey, Suzanne B Kartal, Kinyas Li, Clara Yala, Adam Barzilay, Regina Faulkner, Heather R King, Tari A Acevedo, Francisco Garber, Judy E Guidi, Anthony J Hughes, Kevin S |
| author_sort | Coopey, Suzanne B |
| collection | MIT |
| description | Abstract
Purpose
Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men.
Methods
Review of 932 males with breast pathology was performed to identify cases of ADH. Patients were excluded if ADH was upgraded to cancer on excision, or if they had contralateral breast cancer. Cases were reviewed to determine whether any male with ADH developed breast cancer.
Results
Nineteen males were diagnosed with ADH from June 2003 to September 2018. All had gynecomastia. Surgical procedure was mastectomy in 8 patients and excision/reduction in 11. One patient had their nipple areola complex removed, and 1 required a free nipple graft. Median patient age at ADH diagnosis was 25 years (range 18–72 years). Of the 14 patients with bilateral gynecomastia, 10 had bilateral ADH and 4 had unilateral. Five cases of ADH were described as severe, bordering on ductal carcinoma in situ. No patient reported a family history of breast cancer. No patient took tamoxifen. At a mean follow-up of 75 months (range 4–185 months), no patient developed breast cancer.
Conclusion
Our study is the first to provide follow-up information for males with ADH. With 6 years of mean follow-up, no male in our series has developed breast cancer. This suggests that either ADH in men does not pose the same risk as ADH in women or that surgical excision of symptomatic gynecomastia in men effectively reduces the risk of breast cancer. |
| first_indexed | 2024-09-23T12:27:15Z |
| format | Article |
| id | mit-1721.1/131908 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:27:15Z |
| publishDate | 2021 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1319082021-09-21T03:36:11Z Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? Coopey, Suzanne B Kartal, Kinyas Li, Clara Yala, Adam Barzilay, Regina Faulkner, Heather R King, Tari A Acevedo, Francisco Garber, Judy E Guidi, Anthony J Hughes, Kevin S Abstract Purpose Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men. Methods Review of 932 males with breast pathology was performed to identify cases of ADH. Patients were excluded if ADH was upgraded to cancer on excision, or if they had contralateral breast cancer. Cases were reviewed to determine whether any male with ADH developed breast cancer. Results Nineteen males were diagnosed with ADH from June 2003 to September 2018. All had gynecomastia. Surgical procedure was mastectomy in 8 patients and excision/reduction in 11. One patient had their nipple areola complex removed, and 1 required a free nipple graft. Median patient age at ADH diagnosis was 25 years (range 18–72 years). Of the 14 patients with bilateral gynecomastia, 10 had bilateral ADH and 4 had unilateral. Five cases of ADH were described as severe, bordering on ductal carcinoma in situ. No patient reported a family history of breast cancer. No patient took tamoxifen. At a mean follow-up of 75 months (range 4–185 months), no patient developed breast cancer. Conclusion Our study is the first to provide follow-up information for males with ADH. With 6 years of mean follow-up, no male in our series has developed breast cancer. This suggests that either ADH in men does not pose the same risk as ADH in women or that surgical excision of symptomatic gynecomastia in men effectively reduces the risk of breast cancer. 2021-09-20T17:30:53Z 2021-09-20T17:30:53Z 2019-01-21 2020-09-24T21:35:23Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/131908 en https://doi.org/10.1007/s10549-018-05117-4 Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Springer Science+Business Media, LLC, part of Springer Nature application/pdf Springer US Springer US |
| spellingShingle | Coopey, Suzanne B Kartal, Kinyas Li, Clara Yala, Adam Barzilay, Regina Faulkner, Heather R King, Tari A Acevedo, Francisco Garber, Judy E Guidi, Anthony J Hughes, Kevin S Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? |
| title | Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? |
| title_full | Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? |
| title_fullStr | Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? |
| title_full_unstemmed | Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? |
| title_short | Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk? |
| title_sort | atypical ductal hyperplasia in men with gynecomastia what is their breast cancer risk |
| url | https://hdl.handle.net/1721.1/131908 |
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