The role of Micro-CT in imaging breast cancer specimens
Abstract Purpose The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full 3-dimensional information on the specimen makes this difficult to achieve. Method Micro-CT is a high resolution, X-ray, 3D imaging method, widely used in i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer US
2021
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| Online Access: | https://hdl.handle.net/1721.1/131909 |
| _version_ | 1826192812761153536 |
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| author | DiCorpo, Daniel Tiwari, Ankur Tang, Rong Griffin, Molly Aftreth, Owen Bautista, Pinky Hughes, Kevin Gershenfeld, Neil Michaelson, James |
| author_facet | DiCorpo, Daniel Tiwari, Ankur Tang, Rong Griffin, Molly Aftreth, Owen Bautista, Pinky Hughes, Kevin Gershenfeld, Neil Michaelson, James |
| author_sort | DiCorpo, Daniel |
| collection | MIT |
| description | Abstract
Purpose
The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full 3-dimensional information on the specimen makes this difficult to achieve.
Method
Micro-CT is a high resolution, X-ray, 3D imaging method, widely used in industry but rarely in medicine.
Results
We imaged and analyzed 173 partial mastectomies (129 ductal carcinomas, 14 lobular carcinomas, 28 DCIS). Imaging was simple and rapid. The size and shape of the cancers seen on Micro-CT closely matched the size and shape of the cancers seen at specimen dissection. Micro-CT images of multicentric/multifocal cancers revealed multiple non-contiguous masses. Micro-CT revealed cancer touching the specimen edge for 93% of the 114 cases judged margin positive by the pathologist, and 28 of the cases not seen as margin positive on pathological analysis; cancer occupied 1.55% of surface area when both the pathologist and Micro-CT suggested cancer at the edge, but only 0.45% of surface area for the “Micro-CT-Only-Positive Cases”. Thus, Micro-CT detects cancers that touch a very small region of the specimen surface, which is likely to be missed on sectioning.
Conclusions
Micro-CT provides full 3D images of breast cancer specimens, allowing one to identify, in minutes rather than hours, while the patient is in OR, margin-positive cancers together with information on where the cancer touches the edge, in a fashion more accurate than possible from the histology slides alone. |
| first_indexed | 2024-09-23T09:29:35Z |
| format | Article |
| id | mit-1721.1/131909 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:29:35Z |
| publishDate | 2021 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1319092021-09-21T03:58:25Z The role of Micro-CT in imaging breast cancer specimens DiCorpo, Daniel Tiwari, Ankur Tang, Rong Griffin, Molly Aftreth, Owen Bautista, Pinky Hughes, Kevin Gershenfeld, Neil Michaelson, James Abstract Purpose The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full 3-dimensional information on the specimen makes this difficult to achieve. Method Micro-CT is a high resolution, X-ray, 3D imaging method, widely used in industry but rarely in medicine. Results We imaged and analyzed 173 partial mastectomies (129 ductal carcinomas, 14 lobular carcinomas, 28 DCIS). Imaging was simple and rapid. The size and shape of the cancers seen on Micro-CT closely matched the size and shape of the cancers seen at specimen dissection. Micro-CT images of multicentric/multifocal cancers revealed multiple non-contiguous masses. Micro-CT revealed cancer touching the specimen edge for 93% of the 114 cases judged margin positive by the pathologist, and 28 of the cases not seen as margin positive on pathological analysis; cancer occupied 1.55% of surface area when both the pathologist and Micro-CT suggested cancer at the edge, but only 0.45% of surface area for the “Micro-CT-Only-Positive Cases”. Thus, Micro-CT detects cancers that touch a very small region of the specimen surface, which is likely to be missed on sectioning. Conclusions Micro-CT provides full 3D images of breast cancer specimens, allowing one to identify, in minutes rather than hours, while the patient is in OR, margin-positive cancers together with information on where the cancer touches the edge, in a fashion more accurate than possible from the histology slides alone. 2021-09-20T17:30:54Z 2021-09-20T17:30:54Z 2020-02-04 2020-09-24T21:35:36Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/131909 en https://doi.org/10.1007/s10549-020-05547-z Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Springer Science+Business Media, LLC, part of Springer Nature application/pdf Springer US Springer US |
| spellingShingle | DiCorpo, Daniel Tiwari, Ankur Tang, Rong Griffin, Molly Aftreth, Owen Bautista, Pinky Hughes, Kevin Gershenfeld, Neil Michaelson, James The role of Micro-CT in imaging breast cancer specimens |
| title | The role of Micro-CT in imaging breast cancer specimens |
| title_full | The role of Micro-CT in imaging breast cancer specimens |
| title_fullStr | The role of Micro-CT in imaging breast cancer specimens |
| title_full_unstemmed | The role of Micro-CT in imaging breast cancer specimens |
| title_short | The role of Micro-CT in imaging breast cancer specimens |
| title_sort | role of micro ct in imaging breast cancer specimens |
| url | https://hdl.handle.net/1721.1/131909 |
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