An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand
Copyright © 2020 American Chemical Society. Alkyl-ligated iron-sulfur clusters in the [Fe4S4]3+ charge state have been proposed as short-lived intermediates in a number of enzymatic reactions. To better understand the properties of these intermediates, we have prepared and characterized the first sy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society (ACS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/132591 |
| _version_ | 1826210456960761856 |
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| author | McSkimming, A Sridharan, A Thompson, NB Müller, P Suess, DLM |
| author_facet | McSkimming, A Sridharan, A Thompson, NB Müller, P Suess, DLM |
| author_sort | McSkimming, A |
| collection | MIT |
| description | Copyright © 2020 American Chemical Society. Alkyl-ligated iron-sulfur clusters in the [Fe4S4]3+ charge state have been proposed as short-lived intermediates in a number of enzymatic reactions. To better understand the properties of these intermediates, we have prepared and characterized the first synthetic [Fe4S4]3+-Alkyl cluster. Isolation of this highly reactive species was made possible by the development of an expanded scorpionate ligand suited to the encapsulation of cuboidal clusters. Like the proposed enzymatic intermediates, this synthetic [Fe4S4]3+-Alkyl cluster adopts an S = 1/2 ground state with giso > 2. Mössbauer spectroscopic studies reveal that the alkylated Fe has an unusually low isomer shift, which reflects the highly covalent Fe-C bond and the localization of Fe3+ at the alkylated site in the solid state. Paramagnetic 1H NMR studies establish that this valence localization persists in solution at physiologically relevant temperatures, an effect that has not been observed for [Fe4S4]3+ clusters outside of a protein. These findings establish the unusual electronic-structure effects imparted by the strong-field alkyl ligand and lay the foundation for understanding the electronic structures of [Fe4S4]3+-Alkyl intermediates in biology. |
| first_indexed | 2024-09-23T14:50:11Z |
| format | Article |
| id | mit-1721.1/132591 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:50:11Z |
| publishDate | 2021 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1325912021-09-21T03:17:32Z An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand McSkimming, A Sridharan, A Thompson, NB Müller, P Suess, DLM Copyright © 2020 American Chemical Society. Alkyl-ligated iron-sulfur clusters in the [Fe4S4]3+ charge state have been proposed as short-lived intermediates in a number of enzymatic reactions. To better understand the properties of these intermediates, we have prepared and characterized the first synthetic [Fe4S4]3+-Alkyl cluster. Isolation of this highly reactive species was made possible by the development of an expanded scorpionate ligand suited to the encapsulation of cuboidal clusters. Like the proposed enzymatic intermediates, this synthetic [Fe4S4]3+-Alkyl cluster adopts an S = 1/2 ground state with giso > 2. Mössbauer spectroscopic studies reveal that the alkylated Fe has an unusually low isomer shift, which reflects the highly covalent Fe-C bond and the localization of Fe3+ at the alkylated site in the solid state. Paramagnetic 1H NMR studies establish that this valence localization persists in solution at physiologically relevant temperatures, an effect that has not been observed for [Fe4S4]3+ clusters outside of a protein. These findings establish the unusual electronic-structure effects imparted by the strong-field alkyl ligand and lay the foundation for understanding the electronic structures of [Fe4S4]3+-Alkyl intermediates in biology. 2021-09-20T18:23:13Z 2021-09-20T18:23:13Z 2020-11-12T19:12:43Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/132591 en 10.1021/jacs.0c06334 Journal of the American Chemical Society Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | McSkimming, A Sridharan, A Thompson, NB Müller, P Suess, DLM An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand |
| title | An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand |
| title_full | An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand |
| title_fullStr | An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand |
| title_full_unstemmed | An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand |
| title_short | An [Fe<inf>4</inf>S<inf>4</inf>]<sup>3+</sup>-Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand |
| title_sort | fe inf 4 inf s inf 4 inf sup 3 sup alkyl cluster stabilized by an expanded scorpionate ligand |
| url | https://hdl.handle.net/1721.1/132591 |
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