Microgel encapsulated nanoparticles for glucose-responsive insulin delivery
An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial. However, the challenge o...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/132608 |
| _version_ | 1811079081893036032 |
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| author | Volpatti, Lisa R Facklam, Amanda L. Cortinas, Abel Bryan Lu, Yen-Chun Matranga, Morgan A. MacIsaac, Corina Hill, Michael C. Langer, Robert S Anderson, Daniel Griffith |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Volpatti, Lisa R Facklam, Amanda L. Cortinas, Abel Bryan Lu, Yen-Chun Matranga, Morgan A. MacIsaac, Corina Hill, Michael C. Langer, Robert S Anderson, Daniel Griffith |
| author_sort | Volpatti, Lisa R |
| collection | MIT |
| description | An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial. However, the challenge of achieving desirable release kinetics (i.e., insulin release within minutes after glucose elevation and duration of release on the order of weeks) still remains. Here, we develop a glucose-responsive delivery system using encapsulated glucose-responsive, acetalated-dextran nanoparticles in porous alginate microgels. The nanoparticles respond rapidly to changes in glucose concentrations while the microgels provide them with protection and stability, allowing for extended glucose-responsive insulin release. This system reduces blood sugar in a diabetic mouse model at a rate similar to naked insulin and responds to a glucose challenge 3 days after administration similarly to a healthy animal. With 2 doses of microgels containing 60 IU/kg insulin each, we are able to achieve extended glycemic control in diabetic mice for 22 days. |
| first_indexed | 2024-09-23T11:09:45Z |
| format | Article |
| id | mit-1721.1/132608 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:09:45Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1326082023-02-06T05:02:19Z Microgel encapsulated nanoparticles for glucose-responsive insulin delivery Volpatti, Lisa R Facklam, Amanda L. Cortinas, Abel Bryan Lu, Yen-Chun Matranga, Morgan A. MacIsaac, Corina Hill, Michael C. Langer, Robert S Anderson, Daniel Griffith Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial. However, the challenge of achieving desirable release kinetics (i.e., insulin release within minutes after glucose elevation and duration of release on the order of weeks) still remains. Here, we develop a glucose-responsive delivery system using encapsulated glucose-responsive, acetalated-dextran nanoparticles in porous alginate microgels. The nanoparticles respond rapidly to changes in glucose concentrations while the microgels provide them with protection and stability, allowing for extended glucose-responsive insulin release. This system reduces blood sugar in a diabetic mouse model at a rate similar to naked insulin and responds to a glucose challenge 3 days after administration similarly to a healthy animal. With 2 doses of microgels containing 60 IU/kg insulin each, we are able to achieve extended glycemic control in diabetic mice for 22 days. National Cancer Institute (Grant P30-CA14051) 2021-09-21T14:24:36Z 2021-09-21T14:24:36Z 2020-11 2020-10 2021-09-17T17:06:02Z Article http://purl.org/eprint/type/JournalArticle 0142-9612 https://hdl.handle.net/1721.1/132608 Volpatti, Lisa R. et al. "Microgel encapsulated nanoparticles for glucose-responsive insulin delivery." Biomaterials 267 (January 2021): 120458. © 2020 en http://dx.doi.org/10.1016/j.biomaterials.2020.120458 Biomaterials Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Prof. Anderson via Ye Li |
| spellingShingle | Volpatti, Lisa R Facklam, Amanda L. Cortinas, Abel Bryan Lu, Yen-Chun Matranga, Morgan A. MacIsaac, Corina Hill, Michael C. Langer, Robert S Anderson, Daniel Griffith Microgel encapsulated nanoparticles for glucose-responsive insulin delivery |
| title | Microgel encapsulated nanoparticles for glucose-responsive insulin delivery |
| title_full | Microgel encapsulated nanoparticles for glucose-responsive insulin delivery |
| title_fullStr | Microgel encapsulated nanoparticles for glucose-responsive insulin delivery |
| title_full_unstemmed | Microgel encapsulated nanoparticles for glucose-responsive insulin delivery |
| title_short | Microgel encapsulated nanoparticles for glucose-responsive insulin delivery |
| title_sort | microgel encapsulated nanoparticles for glucose responsive insulin delivery |
| url | https://hdl.handle.net/1721.1/132608 |
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