Reduction of the therapeutic dose of silencing RNA via its integration into the backbone of a pre-microRNA highly enriched in exosome-like vesicles

Reduction of the therapeutic dose of silencing RNA via its integration into the backbone of a pre-microRNA highly enriched in exosome-like vesicles

A small percentage of the short interfering RNA (siRNA) delivered via passive lipid nanoparticles and other delivery vehicles reaches the cytoplasm of cells. The high doses of siRNA and delivery vehicle that are thus required to achieve therapeutic outcomes can lead to toxicity. Here, we show that t...

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Bibliographic Details
Main Authors: Reshke, Ryan, Taylor, James A., Savard, Alexandre, Guo, Huishan, Rhym, Luke Hyunsik, Kowalski, Piotr S, Trung, My Tran, Campbell, Charles, Little, Wheaton, Anderson, Daniel Griffith, Gibbings, Derrick
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/132611

Internet

https://hdl.handle.net/1721.1/132611

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