Reduction of the therapeutic dose of silencing RNA via its integration into the backbone of a pre-microRNA highly enriched in exosome-like vesicles
A small percentage of the short interfering RNA (siRNA) delivered via passive lipid nanoparticles and other delivery vehicles reaches the cytoplasm of cells. The high doses of siRNA and delivery vehicle that are thus required to achieve therapeutic outcomes can lead to toxicity. Here, we show that t...
Main Authors: | Reshke, Ryan, Taylor, James A., Savard, Alexandre, Guo, Huishan, Rhym, Luke Hyunsik, Kowalski, Piotr S, Trung, My Tran, Campbell, Charles, Little, Wheaton, Anderson, Daniel Griffith, Gibbings, Derrick |
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Other Authors: | Koch Institute for Integrative Cancer Research at MIT |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2021
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Online Access: | https://hdl.handle.net/1721.1/132611 |
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