Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers
This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dime...
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| Format: | Article |
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Frontiers Media SA
2021
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| Online Access: | https://hdl.handle.net/1721.1/132624 |
| _version_ | 1826212193548369920 |
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| author | Gleason, Karen K |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Gleason, Karen K |
| author_sort | Gleason, Karen K |
| collection | MIT |
| description | This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release. |
| first_indexed | 2024-09-23T15:17:29Z |
| format | Article |
| id | mit-1721.1/132624 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:17:29Z |
| publishDate | 2021 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1326242022-09-29T13:59:01Z Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers Gleason, Karen K Massachusetts Institute of Technology. Department of Chemical Engineering This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release. 2021-09-22T14:43:51Z 2021-09-22T14:43:51Z 2021-01 2020-11 Article http://purl.org/eprint/type/JournalArticle 2296-4185 https://hdl.handle.net/1721.1/132624 Gleason, Karen K. "Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers." Frontiers in Bioengineering and Biotechnology (January 2021): 632753. © 2021 Gleason https://doi.org/10.3389/fbioe.2021.632753 Frontiers in Bioengineering and Biotechnology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media SA Frontiers |
| spellingShingle | Gleason, Karen K Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_full | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_fullStr | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_full_unstemmed | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_short | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_sort | controlled release utilizing initiated chemical vapor deposited icvd of polymeric nanolayers |
| url | https://hdl.handle.net/1721.1/132624 |
| work_keys_str_mv | AT gleasonkarenk controlledreleaseutilizinginitiatedchemicalvapordepositedicvdofpolymericnanolayers |