Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets
Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact lin...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/132715 |
| _version_ | 1826199325914431488 |
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| author | Kim, Seok Kim, Woo Young Nam, Sang-Hoon Shin, Seunghang Choi, Su Hyun Kim, Do Hyeog Lee, Heedoo Choi, Hyeok Jae Lee, Eungman Park, Jung-Hyun Jo, Inho Fang, Nicholas Xuanlai Cho, Young Tae |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Kim, Seok Kim, Woo Young Nam, Sang-Hoon Shin, Seunghang Choi, Su Hyun Kim, Do Hyeog Lee, Heedoo Choi, Hyeok Jae Lee, Eungman Park, Jung-Hyun Jo, Inho Fang, Nicholas Xuanlai Cho, Young Tae |
| author_sort | Kim, Seok |
| collection | MIT |
| description | Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultraviolet-based nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets. |
| first_indexed | 2024-09-23T11:18:24Z |
| format | Article |
| id | mit-1721.1/132715 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:18:24Z |
| publishDate | 2021 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1327152022-09-27T18:36:21Z Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets Kim, Seok Kim, Woo Young Nam, Sang-Hoon Shin, Seunghang Choi, Su Hyun Kim, Do Hyeog Lee, Heedoo Choi, Hyeok Jae Lee, Eungman Park, Jung-Hyun Jo, Inho Fang, Nicholas Xuanlai Cho, Young Tae Massachusetts Institute of Technology. Department of Mechanical Engineering Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultraviolet-based nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets. 2021-10-05T13:55:47Z 2021-10-05T13:55:47Z 2021-08 2021-02 2021-10-04T16:18:41Z Article http://purl.org/eprint/type/JournalArticle 1936-0851 1936-086X https://hdl.handle.net/1721.1/132715 Kim, Seok et al. "Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets." ACS Nano 15, 9 (August 2021): 14049−14060. © 2021 The Authors en http://dx.doi.org/10.1021/acsnano.1c01636 ACS Nano Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Kim, Seok Kim, Woo Young Nam, Sang-Hoon Shin, Seunghang Choi, Su Hyun Kim, Do Hyeog Lee, Heedoo Choi, Hyeok Jae Lee, Eungman Park, Jung-Hyun Jo, Inho Fang, Nicholas Xuanlai Cho, Young Tae Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets |
| title | Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets |
| title_full | Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets |
| title_fullStr | Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets |
| title_full_unstemmed | Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets |
| title_short | Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets |
| title_sort | microstructured surfaces for reducing chances of fomite transmission via virus containing respiratory droplets |
| url | https://hdl.handle.net/1721.1/132715 |
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