Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment
Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2021
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| Online Access: | https://hdl.handle.net/1721.1/132948 |
| _version_ | 1811070729724100608 |
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| author | Chen, Wuhe Thorn, Frank Deng, Ruzhi Li, Xiaoman Lou, Jiangtao Wang, Yingjie Yu, Xinping |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Chen, Wuhe Thorn, Frank Deng, Ruzhi Li, Xiaoman Lou, Jiangtao Wang, Yingjie Yu, Xinping |
| author_sort | Chen, Wuhe |
| collection | MIT |
| description | Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic amblyopia (median, 8 years old) were enrolled along with 66 healthy controls of similar age and gender distribution. Best-corrected visual acuity (BCVA) was determined, and macular vessel density in the superficial and deep capillary plexuses (SCPs and DCPs, respectively) was measured by optical coherence tomography angiography before and after refractive correction and occlusion therapy. Changes in BCVA and macular SCP and DCP vessel density were measured after amblyopia treatment of 7.5 ± 4.4 months. Results. The amblyopic baseline BCVA, logMAR 0.42 ± 0.27, improved to logMAR 0.18 ± 0.18 in 14 patients (64%) after amblyopia treatment (). In 8 patients (36%), there was no improvement in the BCVA. In amblyopic eyes with improved BCVA, the SCP density tended to increase in each parafoveal quadrant, while it tended to decrease in all quadrants of the fellow eyes. For patients in whom BCVA did not improve, the macular SCP vessel density tended to decrease in all quadrants of the amblyopic and fellow eyes. The posttreatment difference in SCP vessel density between amblyopic and fellow eyes was not significant. Multiple linear regression analysis showed that older age and greater foveal SCP vessel density were negatively correlated with BCVA improvement ( and , respectively). Conclusions. Macular vessel density tends to increase in anisometropic amblyopic eyes after successful treatment. Younger age and lower SCP macular density are predictive of a greater therapeutic effect of occlusion therapy. |
| first_indexed | 2024-09-23T08:40:39Z |
| format | Article |
| id | mit-1721.1/132948 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:40:39Z |
| publishDate | 2021 |
| publisher | Hindawi Limited |
| record_format | dspace |
| spelling | mit-1721.1/1329482022-09-30T10:27:59Z Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment Chen, Wuhe Thorn, Frank Deng, Ruzhi Li, Xiaoman Lou, Jiangtao Wang, Yingjie Yu, Xinping Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic amblyopia (median, 8 years old) were enrolled along with 66 healthy controls of similar age and gender distribution. Best-corrected visual acuity (BCVA) was determined, and macular vessel density in the superficial and deep capillary plexuses (SCPs and DCPs, respectively) was measured by optical coherence tomography angiography before and after refractive correction and occlusion therapy. Changes in BCVA and macular SCP and DCP vessel density were measured after amblyopia treatment of 7.5 ± 4.4 months. Results. The amblyopic baseline BCVA, logMAR 0.42 ± 0.27, improved to logMAR 0.18 ± 0.18 in 14 patients (64%) after amblyopia treatment (). In 8 patients (36%), there was no improvement in the BCVA. In amblyopic eyes with improved BCVA, the SCP density tended to increase in each parafoveal quadrant, while it tended to decrease in all quadrants of the fellow eyes. For patients in whom BCVA did not improve, the macular SCP vessel density tended to decrease in all quadrants of the amblyopic and fellow eyes. The posttreatment difference in SCP vessel density between amblyopic and fellow eyes was not significant. Multiple linear regression analysis showed that older age and greater foveal SCP vessel density were negatively correlated with BCVA improvement ( and , respectively). Conclusions. Macular vessel density tends to increase in anisometropic amblyopic eyes after successful treatment. Younger age and lower SCP macular density are predictive of a greater therapeutic effect of occlusion therapy. 2021-10-13T14:23:22Z 2021-10-13T14:23:22Z 2020-11 2020-10 2020-11-15T08:00:12Z Article http://purl.org/eprint/type/JournalArticle 2090-0058 2090-004X https://hdl.handle.net/1721.1/132948 Wuhe Chen et al. “Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment,” Journal of Ophthalmology (November 2020): 8879175. © 2020 Wuhe Chen et al en http://dx.doi.org/10.1155/2020/8879175 Journal of Ophthamology Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Copyright © 2020 Wuhe Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Limited Journal of Ophthalmology |
| spellingShingle | Chen, Wuhe Thorn, Frank Deng, Ruzhi Li, Xiaoman Lou, Jiangtao Wang, Yingjie Yu, Xinping Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_full | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_fullStr | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_full_unstemmed | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_short | Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment |
| title_sort | macular microvasculature density changes in anisometropic amblyopic eyes after successful treatment |
| url | https://hdl.handle.net/1721.1/132948 |
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