Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

© 2020, The Author(s). In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhances a pre-existing syntheti...

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Bibliographic Details
Main Authors: Kong, Yi Wen, Dreaden, Erik C, Morandell, Sandra, Zhou, Wen, Dhara, Sanjeev S, Sriram, Ganapathy, Lam, Fred C, Patterson, Jesse C, Quadir, Mohiuddin, Dinh, Anh, Shopsowitz, Kevin E, Varmeh, Shohreh, Yilmaz, Ömer H, Lippard, Stephen J, Reinhardt, H Christian, Hemann, Michael T, Hammond, Paula T, Yaffe, Michael B
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/133093

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