Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates

Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates

Antigen accumulation in lymph nodes (LNs) is critical for vaccine efficacy, but understanding of vaccine biodistribution in humans or large animals remains limited. Using the rhesus macaque model, we employed a combination of positron emission tomography (PET) and fluorescence imaging to characteriz...

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Bibliographic Details
Main Authors: Martin, Jacob T, Hartwell, Brittany L, Kumarapperuma, Sidath C, Melo, Mariane B, Carnathan, Diane G, Cossette, Benjamin J, Adams, Josetta, Gong, Siqi, Zhang, Wei, Tokatlian, Talar, Menis, Sergey, Schiffner, Torben, Franklin, Crystal G, Goins, Beth, Fox, Peter T, Silvestri, Guido, Schief, William R, Ruprecht, Ruth M, Irvine, Darrell J
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/133108

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