Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia
Abstract Negative symptoms in the motivational domain are strongly correlated with deficits in social and occupational functioning in schizophrenia. However, the neural substrates underlying these symptoms remain largely unknown. Twenty-eight adults with schizophrenia and twenty healt...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer Berlin Heidelberg
2021
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| Online Access: | https://hdl.handle.net/1721.1/133151 |
| _version_ | 1811093766284509184 |
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| author | Pretus, Clara Bergé, Daniel Guell, Xavier Pérez, Victor Vilarroya, Óscar |
| author_facet | Pretus, Clara Bergé, Daniel Guell, Xavier Pérez, Victor Vilarroya, Óscar |
| author_sort | Pretus, Clara |
| collection | MIT |
| description | Abstract
Negative symptoms in the motivational domain are strongly correlated with deficits in social and occupational functioning in schizophrenia. However, the neural substrates underlying these symptoms remain largely unknown. Twenty-eight adults with schizophrenia and twenty healthy volunteers underwent functional magnetic resonance while completing a lottery game designed to capture reward-related cognitive processes. Each trial demanded an initial investment of effort in form of key presses to increase the odds of winning. Brain activity in response to different reward cues (1 euro versus 1 cent) was compared between groups. Whereas controls invested more effort in improving their chances to win 1 euro compared to 1 cent in the lottery game, patients invested similarly high amounts of effort in both reward conditions. The neuroimaging analysis revealed lower neural activity in the bilateral caudate and cingulo-opercular circuits and decreased effective connectivity between reward-associated areas and neural nodes in the frontoparietal and salience network in response to high- versus low-reward conditions in schizophrenia patients compared to controls. Effective connectivity differences across conditions were associated with amotivation symptoms in patients. Overall, our data provide the evidence of alterations in neural activity in the caudate and cingulo-opercular “task maintenance” circuits and frontoparietal effective connectivity with reward-associated nodes as possible underlying mechanisms of reward value discrimination deficits affecting effort computation in schizophrenia. |
| first_indexed | 2024-09-23T15:50:19Z |
| format | Article |
| id | mit-1721.1/133151 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:50:19Z |
| publishDate | 2021 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1331512021-11-01T14:36:56Z Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia Pretus, Clara Bergé, Daniel Guell, Xavier Pérez, Victor Vilarroya, Óscar Abstract Negative symptoms in the motivational domain are strongly correlated with deficits in social and occupational functioning in schizophrenia. However, the neural substrates underlying these symptoms remain largely unknown. Twenty-eight adults with schizophrenia and twenty healthy volunteers underwent functional magnetic resonance while completing a lottery game designed to capture reward-related cognitive processes. Each trial demanded an initial investment of effort in form of key presses to increase the odds of winning. Brain activity in response to different reward cues (1 euro versus 1 cent) was compared between groups. Whereas controls invested more effort in improving their chances to win 1 euro compared to 1 cent in the lottery game, patients invested similarly high amounts of effort in both reward conditions. The neuroimaging analysis revealed lower neural activity in the bilateral caudate and cingulo-opercular circuits and decreased effective connectivity between reward-associated areas and neural nodes in the frontoparietal and salience network in response to high- versus low-reward conditions in schizophrenia patients compared to controls. Effective connectivity differences across conditions were associated with amotivation symptoms in patients. Overall, our data provide the evidence of alterations in neural activity in the caudate and cingulo-opercular “task maintenance” circuits and frontoparietal effective connectivity with reward-associated nodes as possible underlying mechanisms of reward value discrimination deficits affecting effort computation in schizophrenia. 2021-10-27T16:21:07Z 2021-10-27T16:21:07Z 2020-06-03 2021-05-17T06:27:11Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133151 Pretus, Clara, Bergé, Daniel, Guell, Xavier, Pérez, Victor and Vilarroya, Óscar. 2020. "Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia." en https://doi.org/10.1007/s00406-020-01145-8 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Springer-Verlag GmbH Germany, part of Springer Nature application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Pretus, Clara Bergé, Daniel Guell, Xavier Pérez, Victor Vilarroya, Óscar Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| title | Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| title_full | Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| title_fullStr | Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| title_full_unstemmed | Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| title_short | Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| title_sort | brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia |
| url | https://hdl.handle.net/1721.1/133151 |
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