Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. S...
Main Authors: | O'Shea, Timothy M, Webber, Matthew J, Aimetti, Alex A, Langer, Robert |
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Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | English |
Published: |
Wiley
2021
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Online Access: | https://hdl.handle.net/1721.1/133265 |
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