High-content imaging-based pooled CRISPR screens in mammalian cells

High-content imaging-based pooled CRISPR screens in mammalian cells

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CRISPR (clustered regularly interspaced short palindromic repeats)-based gene inactivation provides a powerful means for linking genes to particular cellular phenotypes. CRISPR-based screening typically uses large genomic pools of single guide RNAs (sgRNAs). However, this approach is limited to phen...

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Bibliographic Details
Main Authors: Yan, Xiaowei, Stuurman, Nico, Ribeiro, Susana A, Tanenbaum, Marvin E, Horlbeck, Max A, Liem, Christina R, Jost, Marco, Weissman, Jonathan S, Vale, Ronald D
Format: Article
Language:English
Published: Rockefeller University Press 2021
Online Access:https://hdl.handle.net/1721.1/133288

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