DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

© 2021, eLife Sciences Publications Ltd. All rights reserved. The committed step of eukaryotic DNA replication occurs when the pairs of Mcm2-7 replicative helicases that license each replication origin are activated. Helicase activation requires the recruitment of Cdc45 and GINS to Mcm2-7, forming C...

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Bibliographic Details
Main Authors: De Jesús-Kim, Lorraine, Friedman, Larry J, Lõoke, Marko, Ramsoomair, Christian K, Gelles, Jeff, Bell, Stephen P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2021
Online Access:https://hdl.handle.net/1721.1/133327

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