Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

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© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. Resistance to immune checkpoint inhibitors (ICIs) is a key challenge in cancer therapy. To elucidate underlying mechanisms, we developed Perturb-CITE-sequencing (Perturb-CITE-seq), enabling pooled clustered regularly int...

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Bibliographic Details
Main Authors: Frangieh, Chris J, Melms, Johannes C, Thakore, Pratiksha I, Geiger-Schuller, Kathryn R, Ho, Patricia, Luoma, Adrienne M, Cleary, Brian, Jerby-Arnon, Livnat, Malu, Shruti, Cuoco, Michael S, Zhao, Maryann, Ager, Casey R, Rogava, Meri, Hovey, Lila, Rotem, Asaf, Bernatchez, Chantale, Wucherpfennig, Kai W, Johnson, Bruce E, Rozenblatt-Rosen, Orit, Schadendorf, Dirk, Regev, Aviv, Izar, Benjamin
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/133360

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https://hdl.handle.net/1721.1/133360

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