Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

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© 2021 National Academy of Sciences. All rights reserved. In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. Because the full complement of these proteins has not been systematically identified, we developed a...

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Bibliographic Details
Main Authors: Condon, Kendall J, Orozco, Jose M, Adelmann, Charles H, Spinelli, Jessica B, van der Helm, Pim W, Roberts, Justin M, Kunchok, Tenzin, Sabatini, David M
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/133370

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