Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales
Connecting the molecular structure and function of chromatin across length and timescales remains a grand challenge to understanding and engineering cellular behaviors. Across five orders of magnitude, dynamic processes constantly reshape chromatin structures, driving spaciotemporal patterns of gene...
| Huvudupphovsmän: | , , , |
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| Övriga upphovsmän: | |
| Materialtyp: | Artikel |
| Språk: | English |
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Elsevier BV
2021
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| Länkar: | https://hdl.handle.net/1721.1/133390 |
| _version_ | 1826216301382598656 |
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| author | Johnstone, Christopher P Wang, Nathan B Sevier, Stuart A Galloway, Kate E |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Johnstone, Christopher P Wang, Nathan B Sevier, Stuart A Galloway, Kate E |
| author_sort | Johnstone, Christopher P |
| collection | MIT |
| description | Connecting the molecular structure and function of chromatin across length and timescales remains a grand challenge to understanding and engineering cellular behaviors. Across five orders of magnitude, dynamic processes constantly reshape chromatin structures, driving spaciotemporal patterns of gene expression and cell fate. Through the interplay of structure and function, the genome operates as a highly dynamic feedback control system. Recent experimental techniques have provided increasingly detailed data that revise and augment the relatively static, hierarchical view of genomic architecture with an understanding of how dynamic processes drive organization. Here, we review how novel technologies from sequencing, imaging, and synthetic biology refine our understanding of chromatin structure and function and enable chromatin engineering. Finally, we discuss opportunities to use these tools to enhance understanding of the dynamic interrelationship of chromatin structure and function. |
| first_indexed | 2024-09-23T16:45:33Z |
| format | Article |
| id | mit-1721.1/133390 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:45:33Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1333902023-01-11T19:34:53Z Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales Johnstone, Christopher P Wang, Nathan B Sevier, Stuart A Galloway, Kate E Massachusetts Institute of Technology. Department of Chemical Engineering Connecting the molecular structure and function of chromatin across length and timescales remains a grand challenge to understanding and engineering cellular behaviors. Across five orders of magnitude, dynamic processes constantly reshape chromatin structures, driving spaciotemporal patterns of gene expression and cell fate. Through the interplay of structure and function, the genome operates as a highly dynamic feedback control system. Recent experimental techniques have provided increasingly detailed data that revise and augment the relatively static, hierarchical view of genomic architecture with an understanding of how dynamic processes drive organization. Here, we review how novel technologies from sequencing, imaging, and synthetic biology refine our understanding of chromatin structure and function and enable chromatin engineering. Finally, we discuss opportunities to use these tools to enhance understanding of the dynamic interrelationship of chromatin structure and function. 2021-10-27T19:52:34Z 2021-10-27T19:52:34Z 2020 2021-06-07T18:26:57Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133390 en 10.1016/j.cels.2020.09.011 Cell Systems Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Johnstone, Christopher P Wang, Nathan B Sevier, Stuart A Galloway, Kate E Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales |
| title | Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales |
| title_full | Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales |
| title_fullStr | Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales |
| title_full_unstemmed | Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales |
| title_short | Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales |
| title_sort | understanding and engineering chromatin as a dynamical system across length and timescales |
| url | https://hdl.handle.net/1721.1/133390 |
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