Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

Cell-based therapies are emerging as effective agents against cancer and other diseases. As autonomous “living drugs,” these therapies lack precise control. Chimeric antigen receptor (CAR) T cells effectively target hematologic malignancies but can proliferate rapidly and cause toxicity. We develope...

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Bibliographic Details
Main Authors: Jan, Max, Scarfò, Irene, Larson, Rebecca C, Walker, Amanda, Schmidts, Andrea, Guirguis, Andrew A, Gasser, Jessica A, Słabicki, Mikołaj, Bouffard, Amanda A, Castano, Ana P, Kann, Michael C, Cabral, Maria L, Tepper, Alexander, Grinshpun, Daniel E, Sperling, Adam S, Kyung, Taeyoon, Sievers, Quinlan L, Birnbaum, Michael E, Maus, Marcela V, Ebert, Benjamin L
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021
Online Access:https://hdl.handle.net/1721.1/133490

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