HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

Defining factors that govern CD8+ T cell immunodominance is critical for the rational design of vaccines for viral pathogens. Here, we assess the contribution of human leukocyte antigen (HLA) class-I-peptide stability for 186 optimal HIV epitopes across 18 HLA alleles using transporter associated wi...

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Bibliographic Details
Main Authors: Kaseke, Clarety, Park, Ryan J, Singh, Nishant K, Koundakjian, Dylan, Bashirova, Arman, Garcia Beltran, Wilfredo F, Takou Mbah, Overbeck C, Ma, Jiaqi, Senjobe, Fernando, Urbach, Jonathan M, Nathan, Anusha, Rossin, Elizabeth J, Tano-Menka, Rhoda, Khatri, Ashok, Piechocka-Trocha, Alicja, Waring, Michael T, Birnbaum, Michael E, Baker, Brian M, Carrington, Mary, Walker, Bruce D, Gaiha, Gaurav D
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/133491

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