Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing

Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing

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Cellular reprogramming suffers from low efficiency especially for the human cells. To deconstruct the heterogeneity and unravel the mechanisms for successful reprogramming, we adopted single-cell RNA sequencing (scRNA-Seq) and single-cell assay for transposase-accessible chromatin (scATAC-Seq) to pr...

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Bibliographic Details
Main Authors: Xing, QR, El Farran, CA, Gautam, P, Chuah, YS, Warrier, T, Toh, CXD, Kang, NY, Sugii, S, Chang, YT, Xu, J, Collins, JJ, Daley, GQ, Li, H, Zhang, LF, Loh, YH
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021
Online Access:https://hdl.handle.net/1721.1/133493

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