Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

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N-Nitrosodimethylamine (NDMA) is a DNA-methylating agent that has been discovered to contaminate water, food, and drugs. The alkyladenine DNA glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understand how gene-environment interactions impact disease...

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Bibliographic Details
Main Authors: Kay, Jennifer E, Corrigan, Joshua J, Armijo, Amanda L, Nazari, Ilana S, Kohale, Ishwar N, Torous, Dorothea K, Avlasevich, Svetlana L, Croy, Robert G, Wadduwage, Dushan N, Carrasco, Sebastian E, Dertinger, Stephen D, White, Forest M, Essigmann, John M, Samson, Leona D, Engelward, Bevin P
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/133516

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