Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
© 2021, The Author(s). We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells, iverm...
Main Authors: | Draganov, D, Han, Z, Rana, A, Bennett, N, Irvine, DJ, Lee, PP |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2022
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Online Access: | https://hdl.handle.net/1721.1/133530.2 |
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