Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
© 2020 Elsevier Inc. Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/133548 |
| _version_ | 1826202130691653632 |
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| author | Sivanand, Sharanya Vander Heiden, Matthew G |
| author_facet | Sivanand, Sharanya Vander Heiden, Matthew G |
| author_sort | Sivanand, Sharanya |
| collection | MIT |
| description | © 2020 Elsevier Inc. Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer. |
| first_indexed | 2024-09-23T12:02:19Z |
| format | Article |
| id | mit-1721.1/133548 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:02:19Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1335482021-10-28T04:07:42Z Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer Sivanand, Sharanya Vander Heiden, Matthew G © 2020 Elsevier Inc. Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer. 2021-10-27T19:53:29Z 2021-10-27T19:53:29Z 2020 2021-08-03T16:36:13Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133548 en 10.1016/J.CCELL.2019.12.011 Cancer Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Sivanand, Sharanya Vander Heiden, Matthew G Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer |
| title | Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer |
| title_full | Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer |
| title_fullStr | Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer |
| title_full_unstemmed | Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer |
| title_short | Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer |
| title_sort | emerging roles for branched chain amino acid metabolism in cancer |
| url | https://hdl.handle.net/1721.1/133548 |
| work_keys_str_mv | AT sivanandsharanya emergingrolesforbranchedchainaminoacidmetabolismincancer AT vanderheidenmatthewg emergingrolesforbranchedchainaminoacidmetabolismincancer |