MalDA, Accelerating Malaria Drug Discovery
© 2021 The Authors The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process by identifying new, essential, druggable targets. In addition, it seeks to produce early lead inh...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/133583 |
| _version_ | 1826189133306920960 |
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| author | Yang, Tuo Ottilie, Sabine Istvan, Eva S Godinez-Macias, Karla P Lukens, Amanda K Baragaña, Beatriz Campo, Brice Walpole, Chris Niles, Jacquin C Chibale, Kelly Dechering, Koen J Llinás, Manuel Lee, Marcus CS Kato, Nobutaka Wyllie, Susan McNamara, Case W Gamo, Francisco Javier Burrows, Jeremy Fidock, David A Goldberg, Daniel E Gilbert, Ian H Wirth, Dyann F Winzeler, Elizabeth A |
| author_facet | Yang, Tuo Ottilie, Sabine Istvan, Eva S Godinez-Macias, Karla P Lukens, Amanda K Baragaña, Beatriz Campo, Brice Walpole, Chris Niles, Jacquin C Chibale, Kelly Dechering, Koen J Llinás, Manuel Lee, Marcus CS Kato, Nobutaka Wyllie, Susan McNamara, Case W Gamo, Francisco Javier Burrows, Jeremy Fidock, David A Goldberg, Daniel E Gilbert, Ian H Wirth, Dyann F Winzeler, Elizabeth A |
| author_sort | Yang, Tuo |
| collection | MIT |
| description | © 2021 The Authors The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process by identifying new, essential, druggable targets. In addition, it seeks to produce early lead inhibitors that may be advanced into drug candidates suitable for preclinical development and subsequent clinical testing in humans. By sharing resources, including expertise, knowledge, materials, and reagents, the consortium strives to eliminate the structural barriers often encountered in the drug discovery process. Here we discuss the mission of the consortium and its scientific achievements, including the identification of new chemically and biologically validated targets, as well as future scientific directions. |
| first_indexed | 2024-09-23T08:10:21Z |
| format | Article |
| id | mit-1721.1/133583 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:10:21Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1335832021-10-28T05:02:01Z MalDA, Accelerating Malaria Drug Discovery Yang, Tuo Ottilie, Sabine Istvan, Eva S Godinez-Macias, Karla P Lukens, Amanda K Baragaña, Beatriz Campo, Brice Walpole, Chris Niles, Jacquin C Chibale, Kelly Dechering, Koen J Llinás, Manuel Lee, Marcus CS Kato, Nobutaka Wyllie, Susan McNamara, Case W Gamo, Francisco Javier Burrows, Jeremy Fidock, David A Goldberg, Daniel E Gilbert, Ian H Wirth, Dyann F Winzeler, Elizabeth A © 2021 The Authors The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process by identifying new, essential, druggable targets. In addition, it seeks to produce early lead inhibitors that may be advanced into drug candidates suitable for preclinical development and subsequent clinical testing in humans. By sharing resources, including expertise, knowledge, materials, and reagents, the consortium strives to eliminate the structural barriers often encountered in the drug discovery process. Here we discuss the mission of the consortium and its scientific achievements, including the identification of new chemically and biologically validated targets, as well as future scientific directions. 2021-10-27T19:53:38Z 2021-10-27T19:53:38Z 2021 2021-09-10T13:06:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133583 en 10.1016/J.PT.2021.01.009 Trends in Parasitology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Yang, Tuo Ottilie, Sabine Istvan, Eva S Godinez-Macias, Karla P Lukens, Amanda K Baragaña, Beatriz Campo, Brice Walpole, Chris Niles, Jacquin C Chibale, Kelly Dechering, Koen J Llinás, Manuel Lee, Marcus CS Kato, Nobutaka Wyllie, Susan McNamara, Case W Gamo, Francisco Javier Burrows, Jeremy Fidock, David A Goldberg, Daniel E Gilbert, Ian H Wirth, Dyann F Winzeler, Elizabeth A MalDA, Accelerating Malaria Drug Discovery |
| title | MalDA, Accelerating Malaria Drug Discovery |
| title_full | MalDA, Accelerating Malaria Drug Discovery |
| title_fullStr | MalDA, Accelerating Malaria Drug Discovery |
| title_full_unstemmed | MalDA, Accelerating Malaria Drug Discovery |
| title_short | MalDA, Accelerating Malaria Drug Discovery |
| title_sort | malda accelerating malaria drug discovery |
| url | https://hdl.handle.net/1721.1/133583 |
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