Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study
© 2020 The Author(s) Emotional dysregulation symptoms in youth frequently predispose individuals to increased risk for mood disorders and other mental health difficulties. These symptoms are also known as a behavioral risk marker in predicting pediatric mood disorders. The underlying neural mechanis...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
|
| Online Access: | https://hdl.handle.net/1721.1/133721 |
| _version_ | 1811080123377516544 |
|---|---|
| author | Hung, Yuwen Uchida, Mai Gaillard, Schuyler L Woodworth, Hilary Kelberman, Caroline Capella, James Kadlec, Kelly Goncalves, Mathias Ghosh, Satrajit Yendiki, Anastasia Chai, Xiaoqian J Hirshfeld-Becker, Dina R Whitfield-Gabrieli, Susan Gabrieli, John DE Biederman, Joseph |
| author2 | Martinos Imaging Center (McGovern Institute for Brain Research at MIT) |
| author_facet | Martinos Imaging Center (McGovern Institute for Brain Research at MIT) Hung, Yuwen Uchida, Mai Gaillard, Schuyler L Woodworth, Hilary Kelberman, Caroline Capella, James Kadlec, Kelly Goncalves, Mathias Ghosh, Satrajit Yendiki, Anastasia Chai, Xiaoqian J Hirshfeld-Becker, Dina R Whitfield-Gabrieli, Susan Gabrieli, John DE Biederman, Joseph |
| author_sort | Hung, Yuwen |
| collection | MIT |
| description | © 2020 The Author(s) Emotional dysregulation symptoms in youth frequently predispose individuals to increased risk for mood disorders and other mental health difficulties. These symptoms are also known as a behavioral risk marker in predicting pediatric mood disorders. The underlying neural mechanism of emotional dysregulation, however, remains unclear. This study used the diffusion tensor imaging (DTI) technique to identify anatomically specific variation in white-matter microstructure that is associated with pediatric emotional dysregulation severity. Thirty-two children (mean age 9.53 years) with varying levels of emotional dysregulation symptoms were recruited by the Massachusetts General Hospital and underwent the DTI scans at Massachusetts Institute of Technology. Emotional dysregulation severity was measured by the empirically-derived Child Behavior Checklist Emotional Dysregulation Profile that includes the Attention, Aggression, and Anxiety/Depression subscales. Whole-brain voxel-wise regression tests revealed significantly increased radial diffusivity (RD) and decreased fractional anisotropy (FA) in the cingulum-callosal regions linked to greater emotional dysregulation in the children. The results suggest that microstructural differences in cingulum-callosal white-matter pathways may manifest as a neurodevelopmental vulnerability for pediatric mood disorders as implicated in the clinical phenotype of pediatric emotional dysregulation. These findings may offer clinically and biologically relevant neural targets for early identification and prevention efforts for pediatric mood disorders. |
| first_indexed | 2024-09-23T11:26:11Z |
| format | Article |
| id | mit-1721.1/133721 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:26:11Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1337212024-03-19T13:38:34Z Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study Hung, Yuwen Uchida, Mai Gaillard, Schuyler L Woodworth, Hilary Kelberman, Caroline Capella, James Kadlec, Kelly Goncalves, Mathias Ghosh, Satrajit Yendiki, Anastasia Chai, Xiaoqian J Hirshfeld-Becker, Dina R Whitfield-Gabrieli, Susan Gabrieli, John DE Biederman, Joseph Martinos Imaging Center (McGovern Institute for Brain Research at MIT) McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Institute for Medical Engineering & Science © 2020 The Author(s) Emotional dysregulation symptoms in youth frequently predispose individuals to increased risk for mood disorders and other mental health difficulties. These symptoms are also known as a behavioral risk marker in predicting pediatric mood disorders. The underlying neural mechanism of emotional dysregulation, however, remains unclear. This study used the diffusion tensor imaging (DTI) technique to identify anatomically specific variation in white-matter microstructure that is associated with pediatric emotional dysregulation severity. Thirty-two children (mean age 9.53 years) with varying levels of emotional dysregulation symptoms were recruited by the Massachusetts General Hospital and underwent the DTI scans at Massachusetts Institute of Technology. Emotional dysregulation severity was measured by the empirically-derived Child Behavior Checklist Emotional Dysregulation Profile that includes the Attention, Aggression, and Anxiety/Depression subscales. Whole-brain voxel-wise regression tests revealed significantly increased radial diffusivity (RD) and decreased fractional anisotropy (FA) in the cingulum-callosal regions linked to greater emotional dysregulation in the children. The results suggest that microstructural differences in cingulum-callosal white-matter pathways may manifest as a neurodevelopmental vulnerability for pediatric mood disorders as implicated in the clinical phenotype of pediatric emotional dysregulation. These findings may offer clinically and biologically relevant neural targets for early identification and prevention efforts for pediatric mood disorders. 2021-10-27T19:56:19Z 2021-10-27T19:56:19Z 2020 2021-03-24T14:08:57Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133721 en 10.1016/J.NICL.2020.102266 NeuroImage: Clinical Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Hung, Yuwen Uchida, Mai Gaillard, Schuyler L Woodworth, Hilary Kelberman, Caroline Capella, James Kadlec, Kelly Goncalves, Mathias Ghosh, Satrajit Yendiki, Anastasia Chai, Xiaoqian J Hirshfeld-Becker, Dina R Whitfield-Gabrieli, Susan Gabrieli, John DE Biederman, Joseph Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study |
| title | Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study |
| title_full | Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study |
| title_fullStr | Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study |
| title_full_unstemmed | Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study |
| title_short | Cingulum-Callosal White-Matter Microstructure Associated with Emotional Dysregulation in Children: A Diffusion Tensor Imaging Study |
| title_sort | cingulum callosal white matter microstructure associated with emotional dysregulation in children a diffusion tensor imaging study |
| url | https://hdl.handle.net/1721.1/133721 |
| work_keys_str_mv | AT hungyuwen cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT uchidamai cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT gaillardschuylerl cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT woodworthhilary cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT kelbermancaroline cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT capellajames cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT kadleckelly cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT goncalvesmathias cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT ghoshsatrajit cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT yendikianastasia cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT chaixiaoqianj cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT hirshfeldbeckerdinar cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT whitfieldgabrielisusan cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT gabrielijohnde cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy AT biedermanjoseph cingulumcallosalwhitemattermicrostructureassociatedwithemotionaldysregulationinchildrenadiffusiontensorimagingstudy |