Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation
© 2021, The Author(s). Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular disease. We hypothesized that a stimulation paradigm using temporal interference (TI) could restore breathing in such conditions. Following opioid overdose in rats, two high frequency (...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/133752 |
| _version_ | 1811084076553076736 |
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| author | Sunshine, Michael D Cassarà, Antonino M Neufeld, Esra Grossman, Nir Mareci, Thomas H Otto, Kevin J Boyden, Edward S Fuller, David D |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Sunshine, Michael D Cassarà, Antonino M Neufeld, Esra Grossman, Nir Mareci, Thomas H Otto, Kevin J Boyden, Edward S Fuller, David D |
| author_sort | Sunshine, Michael D |
| collection | MIT |
| description | © 2021, The Author(s). Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular disease. We hypothesized that a stimulation paradigm using temporal interference (TI) could restore breathing in such conditions. Following opioid overdose in rats, two high frequency (5000 Hz and 5001 Hz), low amplitude waveforms delivered via intramuscular wires in the neck immediately activated the diaphragm and restored ventilation in phase with waveform offset (1 Hz or 60 breaths/min). Following cervical spinal cord injury (SCI), TI stimulation via dorsally placed epidural electrodes uni- or bilaterally activated the diaphragm depending on current and electrode position. In silico modeling indicated that an interferential signal in the ventral spinal cord predicted the evoked response (left versus right diaphragm) and current-ratio-based steering. We conclude that TI stimulation can activate spinal motor neurons after SCI and prevent fatal apnea during drug overdose by restoring ventilation with minimally invasive electrodes. |
| first_indexed | 2024-09-23T12:44:22Z |
| format | Article |
| id | mit-1721.1/133752 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:44:22Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1337522023-11-07T20:06:34Z Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation Sunshine, Michael D Cassarà, Antonino M Neufeld, Esra Grossman, Nir Mareci, Thomas H Otto, Kevin J Boyden, Edward S Fuller, David D Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Program in Media Arts and Sciences (Massachusetts Institute of Technology) Massachusetts Institute of Technology. Department of Biological Engineering McGovern Institute for Brain Research at MIT Koch Institute for Integrative Cancer Research at MIT Howard Hughes Medical Institute © 2021, The Author(s). Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular disease. We hypothesized that a stimulation paradigm using temporal interference (TI) could restore breathing in such conditions. Following opioid overdose in rats, two high frequency (5000 Hz and 5001 Hz), low amplitude waveforms delivered via intramuscular wires in the neck immediately activated the diaphragm and restored ventilation in phase with waveform offset (1 Hz or 60 breaths/min). Following cervical spinal cord injury (SCI), TI stimulation via dorsally placed epidural electrodes uni- or bilaterally activated the diaphragm depending on current and electrode position. In silico modeling indicated that an interferential signal in the ventral spinal cord predicted the evoked response (left versus right diaphragm) and current-ratio-based steering. We conclude that TI stimulation can activate spinal motor neurons after SCI and prevent fatal apnea during drug overdose by restoring ventilation with minimally invasive electrodes. 2021-10-27T19:56:28Z 2021-10-27T19:56:28Z 2021 2021-03-12T15:28:10Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133752 en 10.1038/s42003-020-01604-x Communications Biology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Sunshine, Michael D Cassarà, Antonino M Neufeld, Esra Grossman, Nir Mareci, Thomas H Otto, Kevin J Boyden, Edward S Fuller, David D Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| title | Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| title_full | Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| title_fullStr | Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| title_full_unstemmed | Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| title_short | Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| title_sort | restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation |
| url | https://hdl.handle.net/1721.1/133752 |
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