The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation
Aside from the language-selective left-lateralized fronto-temporal network, language comprehension sometimes recruits a domain-general bilateral fronto-parietal network implicated in executive functions: the multiple demand (MD) network. However, the nature of the MD network's contributions to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Society for Neuroscience
2021
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| Online Access: | https://hdl.handle.net/1721.1/133763 |
| _version_ | 1826199936057737216 |
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| author | Diachek, Evgeniia Blank, Idan Siegelman, Matthew Affourtit, Josef Fedorenko, Evelina |
| author_facet | Diachek, Evgeniia Blank, Idan Siegelman, Matthew Affourtit, Josef Fedorenko, Evelina |
| author_sort | Diachek, Evgeniia |
| collection | MIT |
| description | Aside from the language-selective left-lateralized fronto-temporal network, language comprehension sometimes recruits a domain-general bilateral fronto-parietal network implicated in executive functions: the multiple demand (MD) network. However, the nature of the MD network's contributions to language comprehension remains debated. To illuminate the role of this network in language processing in humans, we conducted a large-scale fMRI investigation using data from 30 diverse word and sentence comprehension experiments (481 unique participants (female and male), 678 scanning sessions). In line with prior findings, the MD network was active during many language tasks. Moreover, similar to the language-selective network, which is robustly lateralized to the left hemisphere, these responses were stronger in the left-hemisphere MD regions. However, in contrast with the language-selective network, the MD network responded more strongly (i) to lists of unconnected words than to sentences, and (ii) in paradigms with an explicit task compared to passive comprehension paradigms. In fact, many passive comprehension tasks failed to elicit a response above the fixation baseline in the MD network, in contrast to strong responses in the language-selective network. Together, these results argue against a role for the MD network in core aspects of sentence comprehension like inhibiting irrelevant meanings or parses, keeping intermediate representations active in working memory, or predicting upcoming words or structures. These results align with recent evidence of relatively poor tracking of the linguistic signal by the MD regions during naturalistic comprehension, and instead suggest that the MD network's engagement during language processing reflects effort associated with extraneous task demands. |
| first_indexed | 2024-09-23T11:28:09Z |
| format | Article |
| id | mit-1721.1/133763 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:28:09Z |
| publishDate | 2021 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/1337632021-10-28T04:16:13Z The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation Diachek, Evgeniia Blank, Idan Siegelman, Matthew Affourtit, Josef Fedorenko, Evelina Aside from the language-selective left-lateralized fronto-temporal network, language comprehension sometimes recruits a domain-general bilateral fronto-parietal network implicated in executive functions: the multiple demand (MD) network. However, the nature of the MD network's contributions to language comprehension remains debated. To illuminate the role of this network in language processing in humans, we conducted a large-scale fMRI investigation using data from 30 diverse word and sentence comprehension experiments (481 unique participants (female and male), 678 scanning sessions). In line with prior findings, the MD network was active during many language tasks. Moreover, similar to the language-selective network, which is robustly lateralized to the left hemisphere, these responses were stronger in the left-hemisphere MD regions. However, in contrast with the language-selective network, the MD network responded more strongly (i) to lists of unconnected words than to sentences, and (ii) in paradigms with an explicit task compared to passive comprehension paradigms. In fact, many passive comprehension tasks failed to elicit a response above the fixation baseline in the MD network, in contrast to strong responses in the language-selective network. Together, these results argue against a role for the MD network in core aspects of sentence comprehension like inhibiting irrelevant meanings or parses, keeping intermediate representations active in working memory, or predicting upcoming words or structures. These results align with recent evidence of relatively poor tracking of the linguistic signal by the MD regions during naturalistic comprehension, and instead suggest that the MD network's engagement during language processing reflects effort associated with extraneous task demands. 2021-10-27T19:56:31Z 2021-10-27T19:56:31Z 2020 2021-03-18T17:53:13Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133763 en 10.1523/JNEUROSCI.2036-19.2020 Journal of Neuroscience Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Society for Neuroscience Journal of Neuroscience |
| spellingShingle | Diachek, Evgeniia Blank, Idan Siegelman, Matthew Affourtit, Josef Fedorenko, Evelina The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation |
| title | The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation |
| title_full | The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation |
| title_fullStr | The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation |
| title_full_unstemmed | The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation |
| title_short | The domain-general multiple demand (MD) network does not support core aspects of language comprehension: a large-scale fMRI investigation |
| title_sort | domain general multiple demand md network does not support core aspects of language comprehension a large scale fmri investigation |
| url | https://hdl.handle.net/1721.1/133763 |
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