Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment
© 2020 Elsevier Inc. Acharya et al. uncover a gradient of increasing glucocorticoid signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes. This gradient regulates effector transition and development of dysfunction. Glucocorticoid is produced locally by tumor-associated monocyte-m...
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| Formatua: | Artikulua |
| Hizkuntza: | English |
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Elsevier BV
2021
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| Sarrera elektronikoa: | https://hdl.handle.net/1721.1/133832 |
| _version_ | 1826198362566688768 |
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| author | Acharya, Nandini Madi, Asaf Zhang, Huiyuan Klapholz, Max Escobar, Giulia Dulberg, Shai Christian, Elena Ferreira, Michelle Dixon, Karen O Fell, Geoffrey Tooley, Katherine Mangani, Davide Xia, Junrong Singer, Meromit Bosenberg, Marcus Neuberg, Donna Rozenblatt-Rosen, Orit Regev, Aviv Kuchroo, Vijay K Anderson, Ana C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Acharya, Nandini Madi, Asaf Zhang, Huiyuan Klapholz, Max Escobar, Giulia Dulberg, Shai Christian, Elena Ferreira, Michelle Dixon, Karen O Fell, Geoffrey Tooley, Katherine Mangani, Davide Xia, Junrong Singer, Meromit Bosenberg, Marcus Neuberg, Donna Rozenblatt-Rosen, Orit Regev, Aviv Kuchroo, Vijay K Anderson, Ana C |
| author_sort | Acharya, Nandini |
| collection | MIT |
| description | © 2020 Elsevier Inc. Acharya et al. uncover a gradient of increasing glucocorticoid signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes. This gradient regulates effector transition and development of dysfunction. Glucocorticoid is produced locally by tumor-associated monocyte-macrophage lineage cells, and presence of active glucocorticoid signaling associates with poor response to immune checkpoint blockade. |
| first_indexed | 2024-09-23T11:03:40Z |
| format | Article |
| id | mit-1721.1/133832 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:03:40Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1338322023-07-21T20:29:35Z Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment Acharya, Nandini Madi, Asaf Zhang, Huiyuan Klapholz, Max Escobar, Giulia Dulberg, Shai Christian, Elena Ferreira, Michelle Dixon, Karen O Fell, Geoffrey Tooley, Katherine Mangani, Davide Xia, Junrong Singer, Meromit Bosenberg, Marcus Neuberg, Donna Rozenblatt-Rosen, Orit Regev, Aviv Kuchroo, Vijay K Anderson, Ana C Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) Howard Hughes Medical Institute © 2020 Elsevier Inc. Acharya et al. uncover a gradient of increasing glucocorticoid signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes. This gradient regulates effector transition and development of dysfunction. Glucocorticoid is produced locally by tumor-associated monocyte-macrophage lineage cells, and presence of active glucocorticoid signaling associates with poor response to immune checkpoint blockade. 2021-10-27T19:56:52Z 2021-10-27T19:56:52Z 2020 2021-09-20T14:33:35Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133832 en 10.1016/J.IMMUNI.2020.08.005 Immunity Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Acharya, Nandini Madi, Asaf Zhang, Huiyuan Klapholz, Max Escobar, Giulia Dulberg, Shai Christian, Elena Ferreira, Michelle Dixon, Karen O Fell, Geoffrey Tooley, Katherine Mangani, Davide Xia, Junrong Singer, Meromit Bosenberg, Marcus Neuberg, Donna Rozenblatt-Rosen, Orit Regev, Aviv Kuchroo, Vijay K Anderson, Ana C Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment |
| title | Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment |
| title_full | Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment |
| title_fullStr | Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment |
| title_full_unstemmed | Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment |
| title_short | Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment |
| title_sort | endogenous glucocorticoid signaling regulates cd8 t cell differentiation and development of dysfunction in the tumor microenvironment |
| url | https://hdl.handle.net/1721.1/133832 |
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