Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vul...
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Bibliographic Details
| Main Authors: |
Lee, Hyeseung,
Fenster, Robert J,
Pineda, S Sebastian,
Gibbs, Whitney S,
Mohammadi, Shahin,
Davila-Velderrain, Jose,
Garcia, Francisco J,
Therrien, Martine,
Novis, Hailey S,
Gao, Fan,
Wilkinson, Hilary,
Vogt, Thomas,
Kellis, Manolis,
LaVoie, Matthew J,
Heiman, Myriam |
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| Other Authors: |
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
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| Format: | Article
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| Language: | English |
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| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/133834
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