Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vul...
| Main Authors: | , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/133834 |
| _version_ | 1811078098042486784 |
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| author | Lee, Hyeseung Fenster, Robert J Pineda, S Sebastian Gibbs, Whitney S Mohammadi, Shahin Davila-Velderrain, Jose Garcia, Francisco J Therrien, Martine Novis, Hailey S Gao, Fan Wilkinson, Hilary Vogt, Thomas Kellis, Manolis LaVoie, Matthew J Heiman, Myriam |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Lee, Hyeseung Fenster, Robert J Pineda, S Sebastian Gibbs, Whitney S Mohammadi, Shahin Davila-Velderrain, Jose Garcia, Francisco J Therrien, Martine Novis, Hailey S Gao, Fan Wilkinson, Hilary Vogt, Thomas Kellis, Manolis LaVoie, Matthew J Heiman, Myriam |
| author_sort | Lee, Hyeseung |
| collection | MIT |
| description | Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD. |
| first_indexed | 2024-09-23T10:53:21Z |
| format | Article |
| id | mit-1721.1/133834 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:53:21Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1338342023-12-06T21:43:07Z Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation Lee, Hyeseung Fenster, Robert J Pineda, S Sebastian Gibbs, Whitney S Mohammadi, Shahin Davila-Velderrain, Jose Garcia, Francisco J Therrien, Martine Novis, Hailey S Gao, Fan Wilkinson, Hilary Vogt, Thomas Kellis, Manolis LaVoie, Matthew J Heiman, Myriam Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD. 2021-10-27T19:56:53Z 2021-10-27T19:56:53Z 2020 2021-09-20T14:40:09Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133834 en 10.1016/J.NEURON.2020.06.021 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Lee, Hyeseung Fenster, Robert J Pineda, S Sebastian Gibbs, Whitney S Mohammadi, Shahin Davila-Velderrain, Jose Garcia, Francisco J Therrien, Martine Novis, Hailey S Gao, Fan Wilkinson, Hilary Vogt, Thomas Kellis, Manolis LaVoie, Matthew J Heiman, Myriam Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation |
| title | Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation |
| title_full | Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation |
| title_fullStr | Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation |
| title_full_unstemmed | Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation |
| title_short | Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation |
| title_sort | cell type specific transcriptomics reveals that mutant huntingtin leads to mitochondrial rna release and neuronal innate immune activation |
| url | https://hdl.handle.net/1721.1/133834 |
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