A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature
© 2017 American Chemical Society. The central dogma of nanoemulsion formation using low-energy methods at constant temperature - popularly known as the emulsion inversion point (EIP) method - is that to create O/W nanoemulsions, water should be added to a mixture of an oil and surfactant. Here, we d...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2021
|
| Online Access: | https://hdl.handle.net/1721.1/133906 |
| _version_ | 1826193210899169280 |
|---|---|
| author | Gupta, Ankur Badruddoza, Abu Zayed Md Doyle, Patrick S |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Gupta, Ankur Badruddoza, Abu Zayed Md Doyle, Patrick S |
| author_sort | Gupta, Ankur |
| collection | MIT |
| description | © 2017 American Chemical Society. The central dogma of nanoemulsion formation using low-energy methods at constant temperature - popularly known as the emulsion inversion point (EIP) method - is that to create O/W nanoemulsions, water should be added to a mixture of an oil and surfactant. Here, we demonstrate that the above order of mixing is not universal and a reverse order of mixing could be superior, depending on the choice of surfactant and liquid phases. We propose a more general methodology to make O/W as well as W/O nanoemulsions by studying the variation of droplet size with the surfactant hydrophilic-lypophilic balance for several model systems. Our analysis shows that surfactant migration from the initial phase to the interface is the critical step for successful nanoemulsion synthesis of both O/W and W/O nanoemulsions. On the basis of our understanding and experimental results, we utilize the reverse order of mixing for two applications: (1) crystallization and formulation of pharmaceutical drugs with faster dissolution rates and (2) synthesis of alginate-based nanogels. The general route provides insights into nanoemulsion formation through low-energy methods and also opens up possibilities that were previously overlooked in the field. |
| first_indexed | 2024-09-23T09:35:23Z |
| format | Article |
| id | mit-1721.1/133906 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:35:23Z |
| publishDate | 2021 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1339062023-02-17T20:37:08Z A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature Gupta, Ankur Badruddoza, Abu Zayed Md Doyle, Patrick S Massachusetts Institute of Technology. Department of Chemical Engineering © 2017 American Chemical Society. The central dogma of nanoemulsion formation using low-energy methods at constant temperature - popularly known as the emulsion inversion point (EIP) method - is that to create O/W nanoemulsions, water should be added to a mixture of an oil and surfactant. Here, we demonstrate that the above order of mixing is not universal and a reverse order of mixing could be superior, depending on the choice of surfactant and liquid phases. We propose a more general methodology to make O/W as well as W/O nanoemulsions by studying the variation of droplet size with the surfactant hydrophilic-lypophilic balance for several model systems. Our analysis shows that surfactant migration from the initial phase to the interface is the critical step for successful nanoemulsion synthesis of both O/W and W/O nanoemulsions. On the basis of our understanding and experimental results, we utilize the reverse order of mixing for two applications: (1) crystallization and formulation of pharmaceutical drugs with faster dissolution rates and (2) synthesis of alginate-based nanogels. The general route provides insights into nanoemulsion formation through low-energy methods and also opens up possibilities that were previously overlooked in the field. 2021-10-27T19:57:10Z 2021-10-27T19:57:10Z 2017 2019-08-16T17:33:51Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133906 en 10.1021/ACS.LANGMUIR.7B01104 Langmuir Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) MIT web domain |
| spellingShingle | Gupta, Ankur Badruddoza, Abu Zayed Md Doyle, Patrick S A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature |
| title | A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature |
| title_full | A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature |
| title_fullStr | A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature |
| title_full_unstemmed | A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature |
| title_short | A General Route for Nanoemulsion Synthesis Using Low-Energy Methods at Constant Temperature |
| title_sort | general route for nanoemulsion synthesis using low energy methods at constant temperature |
| url | https://hdl.handle.net/1721.1/133906 |
| work_keys_str_mv | AT guptaankur ageneralroutefornanoemulsionsynthesisusinglowenergymethodsatconstanttemperature AT badruddozaabuzayedmd ageneralroutefornanoemulsionsynthesisusinglowenergymethodsatconstanttemperature AT doylepatricks ageneralroutefornanoemulsionsynthesisusinglowenergymethodsatconstanttemperature AT guptaankur generalroutefornanoemulsionsynthesisusinglowenergymethodsatconstanttemperature AT badruddozaabuzayedmd generalroutefornanoemulsionsynthesisusinglowenergymethodsatconstanttemperature AT doylepatricks generalroutefornanoemulsionsynthesisusinglowenergymethodsatconstanttemperature |