Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers
Airway stents are often used to maintain patency of the tracheal and bronchial passages in patients suffering from central airway obstruction caused by malignant tumors, scarring, and injury. Like most conventional medical implants, they are designed to perform their functions for a limited period o...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/133918 |
| _version_ | 1826212332777242624 |
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| author | Wang, Jane Boutin, Kyle G Abdulhadi, Omar Personnat, Lyndia D Shazly, Tarek Langer, Robert Channick, Colleen L Borenstein, Jeffrey T |
| author2 | Massachusetts Institute of Technology. Department of Mathematics |
| author_facet | Massachusetts Institute of Technology. Department of Mathematics Wang, Jane Boutin, Kyle G Abdulhadi, Omar Personnat, Lyndia D Shazly, Tarek Langer, Robert Channick, Colleen L Borenstein, Jeffrey T |
| author_sort | Wang, Jane |
| collection | MIT |
| description | Airway stents are often used to maintain patency of the tracheal and bronchial passages in patients suffering from central airway obstruction caused by malignant tumors, scarring, and injury. Like most conventional medical implants, they are designed to perform their functions for a limited period of time, after which surgical removal is often required. Two primary types of airway stents are in general use, metal mesh devices and elastomeric tubes; both are constructed using permanent materials, and must be removed when no longer needed, leading to potential complications. This paper describes the development of process technologies for bioresorbable prototype elastomeric airway stents that would dissolve completely after a predetermined period of time or by an enzymatic triggering mechanism. These airway stents are constructed from biodegradable elastomers with high mechanical strength, flexibility and optical transparency. This work combines microfabrication technology with bioresorbable polymers, with the ultimate goal of a fully biodegradable airway stent ultimately capable of improving patient safety and treatment outcomes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| first_indexed | 2024-09-23T15:20:02Z |
| format | Article |
| id | mit-1721.1/133918 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:20:02Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1339182023-03-15T17:19:11Z Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers Wang, Jane Boutin, Kyle G Abdulhadi, Omar Personnat, Lyndia D Shazly, Tarek Langer, Robert Channick, Colleen L Borenstein, Jeffrey T Massachusetts Institute of Technology. Department of Mathematics Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Airway stents are often used to maintain patency of the tracheal and bronchial passages in patients suffering from central airway obstruction caused by malignant tumors, scarring, and injury. Like most conventional medical implants, they are designed to perform their functions for a limited period of time, after which surgical removal is often required. Two primary types of airway stents are in general use, metal mesh devices and elastomeric tubes; both are constructed using permanent materials, and must be removed when no longer needed, leading to potential complications. This paper describes the development of process technologies for bioresorbable prototype elastomeric airway stents that would dissolve completely after a predetermined period of time or by an enzymatic triggering mechanism. These airway stents are constructed from biodegradable elastomers with high mechanical strength, flexibility and optical transparency. This work combines microfabrication technology with bioresorbable polymers, with the ultimate goal of a fully biodegradable airway stent ultimately capable of improving patient safety and treatment outcomes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2021-10-27T19:57:12Z 2021-10-27T19:57:12Z 2013 2019-09-05T15:50:45Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/133918 Wang, J., et al. "Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(Ester Amide) Elastomers." Advanced Healthcare Materials 2 10 (2013): 1329-36. en 10.1002/ADHM.201200348 Advanced Healthcare Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Wang, Jane Boutin, Kyle G Abdulhadi, Omar Personnat, Lyndia D Shazly, Tarek Langer, Robert Channick, Colleen L Borenstein, Jeffrey T Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers |
| title | Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers |
| title_full | Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers |
| title_fullStr | Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers |
| title_full_unstemmed | Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers |
| title_short | Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers |
| title_sort | fully biodegradable airway stents using amino alcohol based poly ester amide elastomers |
| url | https://hdl.handle.net/1721.1/133918 |
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