Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2(I) C-propeptide domain

Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2(I) C-propeptide domain

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© 2020 Doan et al. Intracellular collagen assembly begins with the oxidative folding of ~30-kDa C-terminal propeptide (C-Pro) domains. Folded C-Pro domains then template the formation of triple helices between appropriate partner strands. Numerous C-Pro missense variants that disrupt or delay triple...

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Bibliographic Details
Main Authors: Doan, Ngoc-Duc, Hosseini, Azade S, Bikovtseva, Agata A, Huang, Michelle S, DiChiara, Andrew S, Papa, Louis J, Koller, Antonius, Shoulders, Matthew D
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134069

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https://hdl.handle.net/1721.1/134069

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