Centrosome-centric view of asymmetric stem cell division
© 2021 The Authors. The centrosome is a unique organelle: the semi-conservative nature of its duplication generates an inherent asymmetry between 'mother' and 'daughter' centrosomes, which differ in their age. This asymmetry has captivated many cell biologists, but its meaning ha...
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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The Royal Society
2021
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| Online Access: | https://hdl.handle.net/1721.1/134098 |
| _version_ | 1811088540873785344 |
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| author | Chen, Cuie Yamashita, Yukiko M |
| author2 | Whitehead Institute for Biomedical Research |
| author_facet | Whitehead Institute for Biomedical Research Chen, Cuie Yamashita, Yukiko M |
| author_sort | Chen, Cuie |
| collection | MIT |
| description | © 2021 The Authors. The centrosome is a unique organelle: the semi-conservative nature of its duplication generates an inherent asymmetry between 'mother' and 'daughter' centrosomes, which differ in their age. This asymmetry has captivated many cell biologists, but its meaning has remained enigmatic. In the last two decades, many stem cell types have been shown to display stereotypical inheritance of either the mother or daughter centrosome. These observations have led to speculation that the mother and daughter centrosomes bear distinct information, contributing to differential cell fates during asymmetric cell divisions. This review summarizes recent progress and discusses how centrosome asymmetry may promote asymmetric fates during stem cell divisions. |
| first_indexed | 2024-09-23T14:03:47Z |
| format | Article |
| id | mit-1721.1/134098 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:03:47Z |
| publishDate | 2021 |
| publisher | The Royal Society |
| record_format | dspace |
| spelling | mit-1721.1/1340982023-02-23T20:34:06Z Centrosome-centric view of asymmetric stem cell division Chen, Cuie Yamashita, Yukiko M Whitehead Institute for Biomedical Research Massachusetts Institute of Technology. Department of Biology Howard Hughes Medical Institute © 2021 The Authors. The centrosome is a unique organelle: the semi-conservative nature of its duplication generates an inherent asymmetry between 'mother' and 'daughter' centrosomes, which differ in their age. This asymmetry has captivated many cell biologists, but its meaning has remained enigmatic. In the last two decades, many stem cell types have been shown to display stereotypical inheritance of either the mother or daughter centrosome. These observations have led to speculation that the mother and daughter centrosomes bear distinct information, contributing to differential cell fates during asymmetric cell divisions. This review summarizes recent progress and discusses how centrosome asymmetry may promote asymmetric fates during stem cell divisions. 2021-10-27T19:58:06Z 2021-10-27T19:58:06Z 2021 2021-08-04T16:30:56Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134098 en 10.1098/rsob.200314 Open Biology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf The Royal Society The Royal Society |
| spellingShingle | Chen, Cuie Yamashita, Yukiko M Centrosome-centric view of asymmetric stem cell division |
| title | Centrosome-centric view of asymmetric stem cell division |
| title_full | Centrosome-centric view of asymmetric stem cell division |
| title_fullStr | Centrosome-centric view of asymmetric stem cell division |
| title_full_unstemmed | Centrosome-centric view of asymmetric stem cell division |
| title_short | Centrosome-centric view of asymmetric stem cell division |
| title_sort | centrosome centric view of asymmetric stem cell division |
| url | https://hdl.handle.net/1721.1/134098 |
| work_keys_str_mv | AT chencuie centrosomecentricviewofasymmetricstemcelldivision AT yamashitayukikom centrosomecentricviewofasymmetricstemcelldivision |