Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients
© 2020 The Authors. Published by Wiley-VCH GmbH Nanoemulsions have become ideal candidates for loading hydrophobic active ingredients and enhancing their bioavailability in the pharmaceutical, food, and cosmetic industries. However, the lack of versatile carrier platforms for nanoemulsions hinders a...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/134101 |
| _version_ | 1811090624067141632 |
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| author | Chen, Liang-Hsun Cheng, Li-Chiun Doyle, Patrick S |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Chen, Liang-Hsun Cheng, Li-Chiun Doyle, Patrick S |
| author_sort | Chen, Liang-Hsun |
| collection | MIT |
| description | © 2020 The Authors. Published by Wiley-VCH GmbH Nanoemulsions have become ideal candidates for loading hydrophobic active ingredients and enhancing their bioavailability in the pharmaceutical, food, and cosmetic industries. However, the lack of versatile carrier platforms for nanoemulsions hinders advanced control over their release behavior. In this work, a method is developed to encapsulate nanoemulsions in alginate capsules for the controlled delivery of lipophilic active ingredients. Functional nanoemulsions loaded with active ingredients and calcium ions are first prepared, followed by encapsulation inside alginate shells. The intrinsically high viscosity of the nanoemulsions ensures the formation of spherical capsules and high encapsulation efficiency during the synthesis. Moreover, a facile approach is developed to measure the nanoemulsion release profile from capsules through UV–vis measurement without an additional extraction step. A quantitative analysis of the release profiles shows that the capsule systems possess a tunable, delayed-burst release. The encapsulation methodology is generalized to other active ingredients, oil phases, nanodroplet sizes, and chemically crosslinked inner hydrogel cores. Overall, the capsule systems provide promising platforms for various functional nanoemulsion formulations. |
| first_indexed | 2024-09-23T14:49:09Z |
| format | Article |
| id | mit-1721.1/134101 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:49:09Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1341012023-02-24T18:02:49Z Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients Chen, Liang-Hsun Cheng, Li-Chiun Doyle, Patrick S Massachusetts Institute of Technology. Department of Chemical Engineering © 2020 The Authors. Published by Wiley-VCH GmbH Nanoemulsions have become ideal candidates for loading hydrophobic active ingredients and enhancing their bioavailability in the pharmaceutical, food, and cosmetic industries. However, the lack of versatile carrier platforms for nanoemulsions hinders advanced control over their release behavior. In this work, a method is developed to encapsulate nanoemulsions in alginate capsules for the controlled delivery of lipophilic active ingredients. Functional nanoemulsions loaded with active ingredients and calcium ions are first prepared, followed by encapsulation inside alginate shells. The intrinsically high viscosity of the nanoemulsions ensures the formation of spherical capsules and high encapsulation efficiency during the synthesis. Moreover, a facile approach is developed to measure the nanoemulsion release profile from capsules through UV–vis measurement without an additional extraction step. A quantitative analysis of the release profiles shows that the capsule systems possess a tunable, delayed-burst release. The encapsulation methodology is generalized to other active ingredients, oil phases, nanodroplet sizes, and chemically crosslinked inner hydrogel cores. Overall, the capsule systems provide promising platforms for various functional nanoemulsion formulations. 2021-10-27T19:58:06Z 2021-10-27T19:58:06Z 2020 2021-06-09T17:29:22Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134101 en 10.1002/ADVS.202001677 Advanced Science Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Chen, Liang-Hsun Cheng, Li-Chiun Doyle, Patrick S Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients |
| title | Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients |
| title_full | Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients |
| title_fullStr | Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients |
| title_full_unstemmed | Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients |
| title_short | Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients |
| title_sort | nanoemulsion loaded capsules for controlled delivery of lipophilic active ingredients |
| url | https://hdl.handle.net/1721.1/134101 |
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